21763-01-9

Basic information

• Product Name: Benzene, (3-chloro-1-phenoxypropyl)-
• Synonyms: 1-phenyl-1-phenoxy-3-chloropropane;3-Chlor-1-phenoxy-1-phenyl-propan;3-phenoxy-3-phenylpropylchloride
• CAS NO: 21763-01-9
• Molecular Formula: C15H15ClO
• Molecular Weight: 246.73200
• Mol File: 21763-01-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzene, (3-chloro-1-phenoxypropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, (3-chloro-1-phenoxypropyl)-(21763-01-9)
• EPA Substance Registry System: Benzene, (3-chloro-1-phenoxypropyl)-(21763-01-9)

Safety Data

• Hazardous Substances Data: 21763-01-9(Hazardous Substances Data)

Upstream product

• 18776-12-0 3-chloro-1-phenyl-propan-1-ol 
• 108-95-2 phenol 
• 21763-00-8 1-bromo-3-chloro-1-phenylpropane 
• 104-52-9 phenylpropyl chloride 
• 936-59-4 3-chloropropiophenone 

Downstream Products

• 1037716-35-0 1-(3-phenoxy-3-phenylpropyl)-1H-imidazole 
• 56161-70-7 N-methyl-3-phenoxy-3-phenyl-1-propylamine 
• 48166-95-6 3-phenyl-3-phenoxypropylamine 

Relevant articles and documents

Aza-Matteson Reactions via Controlled Mono-and Double-Methylene Insertions into Nitrogen-Boron Bonds

Boron-homologation reactions represent an efficient and programmable approach to prepare alkylboronates, which are valuable and versatile synthetic intermediates. The typical boron-homologation reaction, also known as the Matteson reaction, involves formal carbenoid insertions into C-B bonds. Here we report the development of aza-Matteson reactions via carbenoid insertions into the N-B bonds of aminoboranes. By changing the leaving groups of the carbenoids and altering Lewis acid activators, selective mono- and double-methylene insertions can be realized to access various α- and β-boron-substituted tertiary amines, respectively, from common secondary amines. The derivatization of complex amine-containing bioactive molecules, diverse functionalization of the boronate products, and sequential insertions of different carbenoids have also been achieved.

1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies

New 1-[(3-aryloxy-3-aryl)propyl]-1H-imidazoles were synthesized and evaluated against Candida albicans and dermatophytes in order to develop structure-activity relationships (SARs). Against C. albicans the new imidazoles showed minimal inhibitory concentrations (MICs) comparable to those of ketoconazole, miconazole, and econazole, and were more potent than fluconazole. Several derivatives (10, 12, 14, 18-20, 24, 28, 29, 30, and 34) turned out to be potent inhibitors of C. albicans strains resistant to fluconazole, with MIC values less than 10 μg/mL. Against dermatophytes strains, compounds 20, 25, and 33 (MIC ≤ 5 μg/mL) were equipotent to ketoconazole, econazole, and miconazole. SARs of imidazoles 10-44 were rationalized with reasonable accuracy by a previously developed quantitative pharmacophore for antifungal agents.