217817-01-1 Usage
Description
Tos-PEG4-t-butyl ester is a PEG (polyethylene glycol) linker that features a t-butyl ester and a tosyl group. This molecule is designed to enhance solubility in aqueous environments due to the hydrophilic PEG spacer. Additionally, the t-butyl protected carboxyl group can be deprotected under acidic conditions, allowing for further chemical modifications or reactions. The tosyl group serves as an excellent leaving group for nucleophilic substitution reactions, making Tos-PEG4-t-butyl ester a versatile building block in various applications.
Uses
Used in Pharmaceutical Industry:
Tos-PEG4-t-butyl ester is used as a molecular building block for the development of pharmaceutical compounds. Its hydrophilic PEG spacer and t-butyl protected carboxyl group enable the creation of water-soluble drug conjugates, improving the pharmacokinetic properties and bioavailability of the final product.
Used in Chemical Synthesis:
In the field of chemical synthesis, Tos-PEG4-t-butyl ester is used as a versatile intermediate for the synthesis of various complex molecules. The tosyl group's reactivity as a leaving group in nucleophilic substitution reactions allows for the selective introduction of different functional groups, facilitating the construction of diverse chemical libraries.
Used in Bioconjugation:
Tos-PEG4-t-butyl ester is used as a bioconjugation agent to attach biologically active molecules, such as peptides, proteins, or nucleic acids, to other molecules or surfaces. The hydrophilic PEG spacer and t-butyl protected carboxyl group provide a stable and functional platform for the covalent attachment of these biomolecules, enhancing their stability, solubility, and bioactivity.
Used in Drug Delivery Systems:
In the development of drug delivery systems, Tos-PEG4-t-butyl ester is used as a component in the design of targeted drug carriers. The PEG spacer and t-butyl ester can be utilized to improve the solubility and circulation time of drug-loaded nanoparticles or liposomes, while the tosyl group can be employed for the attachment of targeting ligands, enabling selective drug delivery to specific cells or tissues.
Used in Material Science:
In the field of material science, Tos-PEG4-t-butyl ester is used as a component in the development of novel materials with tailored properties. The hydrophilic PEG spacer and t-butyl protected carboxyl group can be incorporated into polymers, gels, or other materials to enhance their solubility, biocompatibility, and responsiveness to environmental stimuli.
Check Digit Verification of cas no
The CAS Registry Mumber 217817-01-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,7,8,1 and 7 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 217817-01:
(8*2)+(7*1)+(6*7)+(5*8)+(4*1)+(3*7)+(2*0)+(1*1)=131
131 % 10 = 1
So 217817-01-1 is a valid CAS Registry Number.
217817-01-1Relevant articles and documents
CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS
-
, (2021/10/30)
Provided are conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and ----- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders.
Quinazoline derivative containing 2-nitroimidazole and application of quinazoline derivative
-
Paragraph 0033-0036, (2021/06/23)
The invention belongs to the field of medicinal chemistry, and particularly relates to a quinazoline derivative of 2-nitroimidazole. The quinazoline derivative has a structure as shown in the specification, wherein R1 and R2 are respectively and independe
A CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS
-
Paragraph 000384; 000385, (2021/03/02)
The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.
