2181-04-6 Usage
Description
Potassium canrenoate, also known as Canrenoic acid, is an aldosterone antagonist derived from plants and is a pharmaceutical compound with various applications in the medical field. It possesses diuretic properties and is used to treat conditions related to fluid retention and high blood pressure.
Uses
Used in Pharmaceutical Industry:
Potassium canrenoate is used as a diuretic for treating conditions related to fluid retention and high blood pressure. It works by blocking the effects of aldosterone, a hormone that regulates the balance of salt and water in the body, leading to increased urine output and reduced fluid buildup.
Used as an Antilipemic Agent:
Potassium canrenoate is used as an antilipemic agent to help lower blood lipid levels, which can contribute to the development of atherosclerosis and other cardiovascular diseases.
Used as an Anticholithogenic Agent:
Potassium canrenoate is also used as an anticholithogenic agent, which means it helps prevent the formation of gallstones by reducing the concentration of cholesterol in the bile.
Brand names for Potassium canrenoate include Aldactone-diurapid, Aldadiene potassium, Kadiur, Lasiren, Luvion, Osirenol, Osyrol-lasix, Phanurane, Sincomen pro injection, Speroctan-m, and Spiroctan.
Originator
Spiroctan,Boehringer
Mannheim,Switz.,1968
Manufacturing Process
The lactone is prepared as follows: A solution of 5 parts of 17α-carboxyethyl-
17β-hydroxyandrost-4-en-3-one lactone and 5 parts of chloranil in 400 parts
of xylene containing a trace of p-toluenesulfonic acid is heated at the boiling
point of the solvent under reflux overnight. The solution is then cooled and
filtered through approximately 200 parts of silica gel. The gel is successively
washed with 5%, 10%, and 15% ethyl acetate-benzene solutions, and the
washings comprising 15% ethyl acetate are thereupon purified by
chromatography on a further quantity of silica gel, using benzene and ethyl
acetate as developing solvents. From the 15% ethyl acetate eluate there is
obtained pure 17α-carboxyethyl-17β-hydroxyandrost-4,6-dien-3-one lactone,
melting at 148° to 151°C. The product solidifies above this melting point and
melts again at 165°C.
Therapeutic Function
Aldosterone antagonist, Diuretic
World Health Organization (WHO)
Potassium canrenoate, which has no intrinsic aldosterone
antagonist activity, owes its therapeutic effect to the enzymatic interconversion in
the body to canrenone. Evidence that long-term administration of high doses are
tumorigenic in the rat has recently led to restriction of its use by some national
regulatory authorities. See also WHO comments for canrenone and spironolactone.
Check Digit Verification of cas no
The CAS Registry Mumber 2181-04-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,8 and 1 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2181-04:
(6*2)+(5*1)+(4*8)+(3*1)+(2*0)+(1*4)=56
56 % 10 = 6
So 2181-04-6 is a valid CAS Registry Number.
InChI:InChI=1/C22H30O4.K/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21,26)12-8-19(24)25;/h3-4,13,16-18,26H,5-12H2,1-2H3,(H,24,25);/q;+1/p-1/t16?,17?,18?,20-,21-,22+;/m0./s1
