21820-51-9 Usage
Description
O-PHOSPHO-L-TYROSINE, also known as a non-proteinogenic L-alpha-amino acid, is L-tyrosine phosphorylated at the phenolic hydroxy group. It is a white solid and plays a significant role in the study of tyrosine-phosphorylation, which is linked to the malignant transformation of cells by various RNA tumor viruses. This phosphorylation process is crucial in signal transduction.
Uses
Used in Pharmaceutical Research:
O-PHOSPHO-L-TYROSINE is used as a research compound for understanding the role of tyrosine-phosphorylation in the malignant transformation of cells by RNA tumor viruses. This knowledge aids in the development of targeted therapies and potential treatments for cancer.
Used in Signal Transduction Studies:
O-PHOSPHO-L-TYROSINE is used as a key molecule in the study of signal transduction pathways. Its role in these pathways helps researchers understand how cells communicate and respond to their environment, which is essential for developing new therapeutic strategies.
Used in Biochemical Education:
O-PHOSPHO-L-TYROSINE serves as an educational tool in biochemistry, providing students with a practical example of a phosphorylated amino acid and its importance in cellular processes and disease mechanisms.
Used in Drug Development:
O-PHOSPHO-L-TYROSINE is used as a starting material or intermediate in the synthesis of potential drugs targeting tyrosine-phosphorylation pathways, which could lead to the development of novel therapeutics for various diseases, including cancer.
Used in Analytical Chemistry:
O-PHOSPHO-L-TYROSINE is used as a reference compound in analytical chemistry for the development and validation of methods to detect and quantify phosphorylated amino acids in biological samples, which is crucial for understanding the role of these molecules in disease processes.
Purification Methods
Purify it by recrystallisation from H2O or H2O/EtOH. [Levene & Schormüller J Biol Chem 100 583 1933, Posternak & Graff Helv Chim Acta 28 1258 1945, Beilstein 14 III 1510.]
Check Digit Verification of cas no
The CAS Registry Mumber 21820-51-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,8,2 and 0 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 21820-51:
(7*2)+(6*1)+(5*8)+(4*2)+(3*0)+(2*5)+(1*1)=79
79 % 10 = 9
So 21820-51-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H12NO6P/c11-7-3-1-6(2-4-7)5-8(9(12)13)10-17(14,15)16/h1-4,8,11H,5H2,(H,12,13)(H3,10,14,15,16)
21820-51-9Relevant articles and documents
A Simple Preparation of O-Phospho-L-tyrosine
Alewood, Paul F.,Johns, R. B.,Valerio, Robert M.,Kemp, Bruce E.
, p. 30 - 31 (1983)
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Asymmetric catalytic synthesis method of L-tyrosine derivative
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Paragraph 0098-0100, (2021/09/08)
The invention relates to an asymmetric catalytic synthesis method of an L-tyrosine derivative, which comprises the following steps of: reacting a compound as shown in a formula (II) with a compound as shown in a formula (III) in the presence of a catalyst as shown in a formula (A), and hydrolyzing to obtain a compound as shown in a formula (I). When the method is used for preparing derivatives such as phosphoric acid or phosphate of L-tyrosine, a large amount of strong acid such as phosphoric acid does not need to be used, the equipment requirement is lowered, the production safety is improved, a large amount of alkali does not need to be adopted for neutralization in post-treatment, generation of a large amount of waste residues such as inorganic salt is avoided, and high economic and environment protection effects are achieved.
Modified synthesis method of oxidative phosphorylation-L-tyrosine
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Paragraph 0022-0023; 0025-0026; 0028-0029; 0030-0032, (2019/01/14)
The invention discloses a modified synthesis method of oxidative phosphorylation-L-tyrosine, and belongs to the field of organic chemistry. L-tyrosine and phosphorus pentoxide are reacted in 85% strong phosphoric acid, a molar ratio of the L-tyrosine to t
