2184-87-4

Basic information

• Product Name: 2-(3,4-dichlorophenyl)propanenitrile
• Synonyms: 2-(3,4-dichlorophenyl)propanenitrile
• CAS NO: 2184-87-4
• Molecular Weight: 200.067
• Mol File: 2184-87-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(3,4-dichlorophenyl)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dichlorophenyl)propanenitrile(2184-87-4)
• EPA Substance Registry System: 2-(3,4-dichlorophenyl)propanenitrile(2184-87-4)

Safety Data

• Hazardous Substances Data: 2184-87-4(Hazardous Substances Data)

Upstream product

• 3218-49-3 3,4-dichloro-benzeneacetonitrile 
• 74-88-4 methyl iodide 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 880347-44-4 2-(3,4-Dichloro-phenyl)-propylamine hydrochloride 

Relevant articles and documents

Selective α-Monomethylation by an Amine-Borane/N,N-Dimethylformamide System as the Methyl Source

A new and practical α-monomethylation strategy using an amine-borane/N,N-dimethylformamide (R3N-BH3/DMF) system as the methyl source was developed. This protocol has been found to be effective in the α-monomethylation of arylacetonitriles and arylacetamides. Mechanistic studies revealed that the formyl group of DMF delivered the carbon and one hydrogen atoms of the methyl group, and R3N-BH3 donated the remaining two hydrogen atoms. Such a unique reaction pathway enabled controllable assemblies of CDH2-, CD2H-, and CD3- units using Me2NH-BH3/d7-DMF, Me3N-BD3/DMF and Me3N-BD3/d7-DMF systems, respectively. Further application of this method to the facile synthesis of anti-inflammatory flurbiprofen and its varied deuterium-labeled derivatives was demonstrated.

SULFONAMIDE COMPOUNDS

Certain sulfonamide compounds are dual CCK1/CCK2 inhibitors useful in the treatment of CCK1/CCK2 mediated diseases.