2185-02-6 Usage
Description
L-HOMOSERINE LACTONE, HYDROCHLORIDE is a chemical compound that is classified as a lactone and is derived from the amino acid L-homoserine. It is commonly used as a synthetic intermediate in the production of various pharmaceuticals and organic compounds. L-HOMOSERINE LACTONE, HYDROCHLORIDE has also been studied for its potential role as a signaling molecule in bacteria and for its potential use in biofilm inhibition and as a quorum sensing inhibitor. Additionally, it has been investigated for its antibacterial and antifungal properties. L-HOMOSERINE LACTONE, HYDROCHLORIDE is soluble in water and is typically stored and handled under controlled conditions due to its potentially hazardous nature.
Uses
Used in Pharmaceutical Industry:
L-HOMOSERINE LACTONE, HYDROCHLORIDE is used as a synthetic intermediate for the production of various pharmaceuticals and organic compounds.
Used in Biotechnology Industry:
L-HOMOSERINE LACTONE, HYDROCHLORIDE is used as a signaling molecule in bacteria for its potential role in biofilm inhibition and as a quorum sensing inhibitor.
Used in Antimicrobial Applications:
L-HOMOSERINE LACTONE, HYDROCHLORIDE is used as an antibacterial and antifungal agent due to its potential properties in inhibiting the growth of certain microorganisms.
Check Digit Verification of cas no
The CAS Registry Mumber 2185-02-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,8 and 5 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 2185-02:
(6*2)+(5*1)+(4*8)+(3*5)+(2*0)+(1*2)=66
66 % 10 = 6
So 2185-02-6 is a valid CAS Registry Number.
InChI:InChI=1/C4H5NO2.ClH/c5-3-1-2-7-4(3)6;/h1-3H,5H2;1H
2185-02-6Relevant articles and documents
De novo synthesis, structural assignment and biological evaluation of pseudopaline, a metallophore produced by Pseudomonas aeruginosa
Zhang, Jian,Zhao, Tianhu,Yang, Rongwen,Siridechakorn, Ittipon,Wang, Sanshan,Guo, Qianqian,Bai, Yingjie,Shen, Hong C.,Lei, Xiaoguang
, p. 6635 - 6641 (2019/07/17)
Pseudopaline is an opine carboxylate metallophore produced by Pseudomonas aeruginosa for harvesting divalent metals. However, the structure of pseudopaline is not fully elucidated. Herein, we report the first de novo total synthesis and isolation of pseudopaline, which allows unambiguous determination and confirmation of both the absolute and the relative configuration of the natural product. The synthesis highlights an efficient and stereocontrolled route using the asymmetric Tsuji-Trost reaction as the key step. The preliminary structure-activity relationship study indicated that one pseudopaline derivative shows comparable activity to pseudopaline. Moreover, a pseudopaline-fluorescein conjugate was prepared and evaluated, which confirmed that pseudopaline could be transported in the bacteria. Since the metal acquisition by P. aeruginosa is crucial for its ability to cause diseases, our extensive structural and functional studies of pseudopaline may pave the way for developing new therapeutic strategies such as the "Trojan horse" antibiotic conjugate against P. aeruginosa.