218608-98-1 Usage
General Description
The chemical BOC-(R)-3-AMINO-4-(2-FLUORO-PHENYL)-BUTYRIC ACID is a compound with the molecular formula C14H18FNO3. It is a derivative of the amino acid valine, with a BOC (tert-butyloxycarbonyl) protecting group attached to the amino group. The compound also contains a 2-fluorophenyl group attached to the carbon chain. This chemical may have potential applications in medicinal chemistry and drug development, particularly in the design of pharmaceuticals targeting specific biological pathways or receptors. Further research and testing are required to fully understand the potential uses and properties of BOC-(R)-3-AMINO-4-(2-FLUORO-PHENYL)-BUTYRIC ACID.
Check Digit Verification of cas no
The CAS Registry Mumber 218608-98-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,8,6,0 and 8 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 218608-98:
(8*2)+(7*1)+(6*8)+(5*6)+(4*0)+(3*8)+(2*9)+(1*8)=151
151 % 10 = 1
So 218608-98-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H20FNO4/c1-15(2,3)21-14(20)17-11(9-13(18)19)8-10-6-4-5-7-12(10)16/h4-7,11H,8-9H2,1-3H3,(H,17,20)(H,18,19)/t11-/m1/s1
218608-98-1Relevant articles and documents
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
