21863-32-1

Basic information

• Product Name: Quinoline, 1,2,3,4-tetrahydro-1-(phenylmethyl)-
• Synonyms: N-benzyltetrahydroquinoline;1-Benzyl-1,2,3,4-tetrahydro-chinolin;N-benzyl-1,2,3,4-tetrahydroquinoline;1-benzyl-1,2,3,4-tetrahydroquinoline;N-benzyl-1,2,3,4-tetrahydroquinaldine
• CAS NO: 21863-32-1
• Molecular Formula: C16H17N
• Molecular Weight: 223.318
• Mol File: 21863-32-1.mol
• Article Data: 28

Chemical Properties

• CAS DataBase Reference: Quinoline, 1,2,3,4-tetrahydro-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 1,2,3,4-tetrahydro-1-(phenylmethyl)-(21863-32-1)
• EPA Substance Registry System: Quinoline, 1,2,3,4-tetrahydro-1-(phenylmethyl)-(21863-32-1)

Safety Data

• Hazardous Substances Data: 21863-32-1(Hazardous Substances Data)

Upstream product

• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 100-51-6 benzyl alcohol 
• 553-03-7 3,4-dihydro-2(1H)-quinolone 
• 100-44-7 benzyl chloride 
• 15619-48-4 1-benzylquinolin-1-ium chloride 
• 16078-38-9 N-benzoyl-1,2,3,4-tetrahydroquinoline 
• 91-22-5 quinoline 
• 100-52-7 benzaldehyde 
• 100-47-0 benzonitrile 
• 101581-87-7 N-phenylmethyl-3-(2-methoxyphenyl)propylamine 
• 146253-19-2 3-(2-methoxyphenyl)propyl methanesulfonate 
• 10493-37-5 3-(2-methoxyphenyl)propan-1-ol 
• 70311-27-2 2-methoxybenzenepropanoic acid ethyl ester 
• 24393-54-2 ethyl 3-(2-methoxyphenyl)prop-2-enoate 

Downstream Products

• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 1438900-67-4 1,1'-dibenzyl-1,1',2,2',3,3',4,4'-octahydro-6,6'-biquinoline 

Relevant articles and documents

Reusable Co-nanoparticles for general and selectiveN-alkylation of amines and ammonia with alcohols

A general cobalt-catalyzedN-alkylation of amines with alcohols by borrowing hydrogen methodology to prepare different kinds of amines is reported. The optimal catalyst for this transformation is prepared by pyrolysis of a specific templated material, which is generatedin situby mixing cobalt salts, nitrogen ligands and colloidal silica, and subsequent removal of silica. Applying this novel Co-nanoparticle-based material, >100 primary, secondary, and tertiary amines includingN-methylamines and selected drug molecules were conveniently prepared starting from inexpensive and easily accessible alcohols and amines or ammonia.

Selective Synthesis of Secondary Amines from Nitriles by a User-Friendly Cobalt Catalyst

Selective hydrogenation/reductive amination of nitriles to secondary amines catalyzed by an inexpensive and user-friendly cobalt complex, (Xantphos)CoCl2, is reported. The use of (Xantphos)CoCl2 and ammonia borane (NH3?BH3) combination affords the selective reduction of nitriles to symmetrical secondary amines, whereas the employment of (Xantphos)CoCl2 and dimethylamine borane (Me2NH?BH3) along with external amines produce unsymmetrical secondary amines and tertiary amines. The general applicability of this methodology is demonstrated by the synthesis of 43 symmetrical and unsymmetrical secondary and tertiary amines bearing diverse functionalities. (Figure presented.).

Radical-mediated direct C-H amination of arenes with secondary amines

Aryl dialkyl amines, valuable subunits of a wide range of effect chemicals, are accessed by intramolecular amination of aromatic C-H bonds employing UV photolysis of N-chloroamines. The reactions show good functional group tolerance and allow access to a range of fused and bridged polycyclic structures. The homogeneous reaction conditions allow for the one-pot conversion of secondary amines to their arylated derivatives. Experimental and theoretical evidence supports the involvement of electrophilic aminium radicals which react via direct ortho-attack on the arene.