218632-36-1Relevant articles and documents
PYRAZOLOPYRIDAZINE DERIVATIVES, PREPARATION METHOD THEREOF AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME
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Paragraph 0203-0204; 0209-0212, (2020/11/14)
The present invention is a pyrazolopyridazine derivative. A pharmaceutical composition for preventing or treating cancer contains the pyrazolopyridazin derivative compound Hsp90 according to the present invention as an active ingredient, which can be used as Hsp90 a pharmaceutical composition for preventing or treating Hsp90-related diseases such as melanoma, brain tumor, breast cancer, lung cancer and the like. (by machine translation)
Microwave-assisted synthesis of tetrazolyl pyrazole amides
Hu, Jun,Wang, Jikui,Zhou, Taoyu,Xu, Yanhua
experimental part, p. 525 - 527 (2011/11/30)
A rapid and efficient microwave-assisted synthesis N-(1H-tetrazol-5-yl) derivatives of 3-methyl-1-phenyl-1H-pyrazole- 5-carboxamide is described. These tetrazole pyrazole amides have interesting bacteriocidal, pesticidal, herbicidal and antimicrobial activities. They were identified by IR and 1H NMR elemental analyses. The target compounds were obtained in a shorter reaction time compared to conventional heating methods.
Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N-[3-fluoro-2′ -(aminosulfonyl)[1,1′-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor
Pruitt, James R.,Pinto, Donald J. P.,Galemmo Jr., Robert A.,Alexander, Richard S.,Rossi, Karen A.,Wells, Brian L.,Drummond, Spencer,Bostrom, Lori L.,Burdick, Debra,Bruckner, Robert,Chen, Haiying,Smallwood, Angela,Wong, Pancras C.,Wright, Matthew R.,Bai, Steven,Luettgen, Joseph M.,Knabb, Robert M.,Lam, Patrick Y. S.,Wexler, Ruth R.
, p. 5298 - 5315 (2007/10/03)
Factor Xa, a serine protease, is at the critical juncture between the intrinsic and extrinsic pathways of the coagulation cascade. Inhibition of factor Xa has the potential to provide effective treatment for both venous and arterial thrombosis. We recentl