2188-18-3 Usage
Description
N-Boc-N'-nitro-L-arginine, also known as Boc-L-Nitroarginine, is a chemical compound derived from L-arginine, an essential amino acid. It is characterized by the presence of a Boc (tert-butyloxycarbonyl) protecting group and a nitro group on the guanidine nitrogen. N-Boc-N'-nitro-L-arginine is widely utilized in various fields due to its unique properties and reactivity.
Uses
Used in Peptide Chemistry:
N-Boc-N'-nitro-L-arginine is used as a protected amino acid for peptide synthesis. The Boc group serves as a temporary protecting group that prevents unwanted side reactions during the peptide assembly process. It is removed under mild acidic conditions once the desired peptide sequence is formed.
Used in Pharmaceutical Research:
N-Boc-N'-nitro-L-arginine is used as a nitric oxide (NO) synthase inhibitor for studying the effects of various compounds on nitric oxide production. Nitric oxide is a crucial signaling molecule involved in numerous physiological processes, including vasodilation, immune response, and neurotransmission. Inhibiting its production can help researchers understand the role of nitric oxide in various diseases and develop potential therapeutic strategies.
Used in Sepsis Treatment Research:
N-Boc-N'-nitro-L-arginine is used as a research tool to study the effects of methylene blue (MB) for the treatment of sepsis induced by bowel perforation. Sepsis is a life-threatening condition caused by the body's response to an infection, and understanding the underlying mechanisms can lead to the development of more effective treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 2188-18-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,8 and 8 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2188-18:
(6*2)+(5*1)+(4*8)+(3*8)+(2*1)+(1*8)=83
83 % 10 = 3
So 2188-18-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H21N5O6/c1-11(2,3)22-10(19)14-7(8(17)18)5-4-6-13-9(12)15-16(20)21/h7H,4-6H2,1-3H3,(H,14,19)(H,17,18)(H3,12,13,15)/t7-/m1/s1
2188-18-3Relevant articles and documents
(Nitro) hymenamide A, unusual biologically active cyclic peptide
Belagali,Himaja,Kumar,Thomas,Prakasini,Poojary
, p. 160 - 164 (2007/10/03)
A new biological active cyclic peptide (Nitro) Hymenamide A has been synthesized and the structure was established on the basis of analytical, IR, NMR and mass spectral data. The new compound was subjected to both antimicrobial and pharmacological studies.
Syntheses of N(α)-(β-naphthylsulfonylaminoglycyl)-argininamides as potential selective synthetic thrombin inhibitors
Etemad-Moghadam,Delebassee,Maffrand,Frehel
, p. 577 - 585 (2007/10/02)
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3-Alkoxycarbonyl-2-oxazolones and Their Homopolymers as Highly Preservable Amino-Protecting Reagents. tert-Butoxy-carbonylation and Benzyloxycarbonylation of Amino Groups
Kunieda, Takehisa,Higuchi, Tsunehiko,Abe, Yoshihiro,Hirobe, Masaaki
, p. 2174 - 2181 (2007/10/02)
Highly preservable amino protecting reagents derived from the 2-oxazolone moiety as a common activating mediator have been developed. 3-Alkoxycarbonyl-2-oxazolones serve as easily handled reagents for amino protection, including tert-butoxycarbonylation, benzyloxycarbonylation, p-methoxybenzyloxycarbonylation, methoxycarbonylation and ethoxycarbonylation.For example, high yield N-protection of α-amino acids has been smoothly performed by the use of 3-tert-butoxycarbonyl and 3-benzyloxycarbonyl-2-oxazolones in aqueous solution at room temperature.A series of homopolymers, poly(3-alkoxycarbonyl-2-oxazolone), is readily obtainable by radical-initiated chain reaction of the corresponding 4,5-unsubstituted oxazolone monomers (except for the tert-butoxy derivate, which failed to give polymeric compounds), and these were successfully used for amino protection as well.Use of the polymer reagents greatly simplifies the purification procedure, though a longer reaction time is required.Keywords - 3-alkoxycarbonyl-2-oxazolone; poly(2-alkoxycarbonyl-2-oxazolone); 3-tert-butoxycarbonyl-2-oxazolone; 3-benzyloxycarbonyl-2-oxazolone; amino protection