21886-58-8

Basic information

• Product Name: Ethanone, 1-(3-bromophenyl)-2-chloro-
• CAS NO: 21886-58-8
• Molecular Formula: C8H6BrClO
• Molecular Weight: 233.492
• Mol File: 21886-58-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(3-bromophenyl)-2-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(3-bromophenyl)-2-chloro-(21886-58-8)
• EPA Substance Registry System: Ethanone, 1-(3-bromophenyl)-2-chloro-(21886-58-8)

Safety Data

• Hazardous Substances Data: 21886-58-8(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(3-bromophenyl)-2-chloro- is a chemical compound with the molecular formula C8H6BrClO. It is a ketone derivative that features a chlorine atom and a bromophenyl group attached to the carbonyl carbon. Ethanone, 1-(3-bromophenyl)-2-chloro- is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals, agrochemicals, and other fine chemicals. It has potential applications in the development of new drugs and materials due to its unique structure and reactivity. However, as with any chemical compound, proper handling and precautions should be taken to ensure safety and minimize potential risks.

Upstream product

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Relevant articles and documents

A practical synthesis of α-bromo/iodo/chloroketones from olefins under visible-light irradiation conditions

A practical synthesis of α-bromo/iodo/chloroketones from olefins under visible-light irradiation conditions has been developed. In the presence of PhI(OAc)2 as promoter and under ambient conditions, the reactions of styrenes and triiodomethane undergo the transformation smoothly to deliver the corresponding α-iodoketones without additional photocatalyst in good yields under sunlight irradiation. Meanwhile, the reactions of styrenes with tribromomethane and trichloromethane generate the desired α-bromoketones and α-chloroketones in high yields by using Ru(bpy)3Cl2 as a photocatalyst under blue LED (450–455 nm) irradiation.

Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease

To develop novel neuroprotective agents, a library of novel arylalkenylpropargylamines was synthesized and tested for inhibitory activities against monoamine oxidases. From this, a number of highly potent and selective monoamine oxidase B inhibitors were identified. Selected compounds were also tested for neuroprotection in in vitro studies with PC-12 cells treated with 6-OHDA and rotenone, respectively. It was observed that some of the compounds tested yielded a marked increase in survival in PC-12 cells treated with the neurotoxins. This indicates that these propargylamines are able to confer protection against the effects of the toxins and may also be considered as novel disease-modifying anti-Parkinsonian agents, which are much needed for the therapy of Parkinson's disease.

Mild and efficient α-chlorination of carbonyl compounds using ammonium chloride and oxone (2KHSO5·KHSO4· K2SO4)

A simple protocol for the α-monochlorination of ketones and 1,3-dicarbonyl compounds utilizing NH4Cl as a source of chlorine and Oxone as an oxidant in methanol without catalyst is presented. The reaction proceeds at ambient temperature in yields ranging from moderate to excellent.