21895-14-7

Basic information

• Product Name: BENZENE,1,1'-METHYLENEBIS[3-M
• Synonyms: BENZENE,1,1'-METHYLENEBIS[3-M
• CAS NO: 21895-14-7
• Molecular Formula: C₁₅H₁₆
• Molecular Weight: 196.28754
• Mol File: 21895-14-7.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BENZENE,1,1'-METHYLENEBIS[3-M(CAS DataBase Reference)
• NIST Chemistry Reference: BENZENE,1,1'-METHYLENEBIS[3-M(21895-14-7)
• EPA Substance Registry System: BENZENE,1,1'-METHYLENEBIS[3-M(21895-14-7)

Safety Data

• Hazardous Substances Data: 21895-14-7(Hazardous Substances Data)

Upstream product

• 13389-72-5 bis(3-methylphenyl)methanol 
• 108-38-3 m-xylene 
• 108-44-1 1-amino-3-methylbenzene 
• 620-19-9 1-chloromethyl-3-methyl-benzene 
• 108-88-3 toluene 
• 591-17-3 meta-bromotoluene 
• 594-27-4 tetramethylstannane 
• 78782-17-9 4,4,5,5-tetramethyl-2-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,3,2-dioxaborolane 
• 98-86-2 acetophenone 
• 110229-59-9 1-methyl-4-((octyloxy)methyl)benzene 
• 75-09-2 dichloromethane 
• 625-95-6 3-Iodotoluene 

Downstream Products

• 67277-73-0 C₁₅H₁₂N₄O₈ 
• 67277-74-1 2-Methyl-4-(5-methyl-2,4-dinitro-benzyl)-1,3,5-trinitro-benzene 
• 68370-90-1 C₂₉H₂₀N₄O₈ 

Relevant articles and documents

Dual Nickel- And Photoredox-Catalyzed Reductive Cross-Coupling of Aryl Halides with Dichloromethane via a Radical Process

The first catalytic strategy to harness a new chloromethane radical from dichloromethane under dual Ni/photoredox catalytic conditions has been developed. Compared with traditional two-electron reductive process associated with metallic reductants, this method via a single-electron approach can proceed under exceptionally mild conditions (visible light, ambient temperature, no strong base) and exhibits complementary reactivity patterns. It affords a broad scope of many functional groups, including alkenyl, which suffers cyclopropanation in previous routes. The diarylmethane-d2 compounds can be readily available with this transformation.

Facile one-pot palladium-catalyzed sequential coupling to diarylmethanes by using aryl methyl ketones as the methylene donors

A novel palladium-catalyzed coupling reaction of an aryl methyl ketone with two molecules of an aryl halide to yield symmetric diarylmethanes is described. In the facile one-pot reaction, the aryl methyl ketone acts as a formal methylene donor. The experimental facts, including TLC monitoring, speculated intermediates as the raw materials, analysis of the cesium benzoate coproduct by ex situ IR spectroscopy, and the cross-coupling reactions of two different aryl halides, indicate a mechanism involving a palladium-catalyzed sequential two-step coupling process, in which the presence of a trace amount of H 2O is indispensable. The reaction is applicable to a broad spectrum of substrates and delivers the products in good to excellent yields. Access to unsymmetrical diarylmethanes with this method is also explored and various factors are discussed. An aryl methyl ketone is used as the methylene donor to couple with two molecules of an aryl halide for the synthesis of various symmetric diarylmethanes under palladium catalysis. The mechanism involves a two-step coupling process in which the presence of a trace amount of H 2O is indispensable. The cross-coupling to unsymmetrical diarylmethanes with this method is also explored. Copyright

Palladium-catalyzed cross-coupling alkylation of arenediazonium o-benzenedisulfonimides

Arenediazonium o-benzenedisulfonimides were reacted with tetramethyltin, tetrabutyltin or trialkylboranes. The reactions, carried out in the presence of palladium(II) derivatives as precatalysts, gave the methylation and alkylation products with good over