21903-56-0

Basic information

• Product Name: 1,2-bis(bromomethyl)-4,5-dichlorobenzene
• Synonyms: o-Xylene, .alpha.,.alpha.'-dibromo-4,5-dichloro
• CAS NO: 21903-56-0
• Molecular Formula: C₈H₆Br₂Cl₂
• Molecular Weight: 332.8472
• Mol File: 21903-56-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 331.2°C at 760 mmHg
• Flash Point: 174.2°C
• Density: 1.931g/cm³
• Vapor Pressure: 0.000305mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: 1,2-bis(bromomethyl)-4,5-dichlorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-bis(bromomethyl)-4,5-dichlorobenzene(21903-56-0)
• EPA Substance Registry System: 1,2-bis(bromomethyl)-4,5-dichlorobenzene(21903-56-0)

Safety Data

• Hazardous Substances Data: 21903-56-0(Hazardous Substances Data)

Usage

General Description

1,2-bis(bromomethyl)-4,5-dichlorobenzene is a chemical compound with the molecular formula C8H6Br2Cl2. It is also known by the trade name Bis(tribromomethyl)benzene. It is a colorless to light yellow liquid with a strong, pungent odor. 1,2-bis(bromomethyl)-4,5-dichlorobenzene is primarily used as a reagent in organic synthesis and as a building block for the production of various pharmaceuticals, agrochemicals, and other fine chemicals. It is also used as a flame retardant and in the production of polymers. However, it is important to handle this chemical with caution as it has been identified as a potential environmental hazard and has been associated with various health risks, particularly in relation to respiratory and skin irritation.

Upstream product

• 24006-92-6 4,5-dichlorobenzene-1,2-dimethanol 
• 942-06-3 4,5-dichlorophthalic anhydride 
• 75-18-3 dimethylsulfide 
• 56962-08-4 4,5-dichlorophthalic acid 
• 106727-86-0 4,5-dichlorophthalic acid dimethyl ester 

Downstream Products

• 285132-01-6 2,6,7-trichloro-1-(β-D-ribofuranosyl)naphtho[2,3-d]imidazole 
• 34588-40-4 2,3,6,7-tetrachloronaphthalene 

Relevant articles and documents

2,3-Dihalo- and 2,3,6,7-Tetrahaloanthracenes by Vollhardt Trimerization

We efficiently synthesized otherwise difficult to obtain 2,3- and 2,3,6,7-halogenated anthracenes with diverse east/west substituents. Key steps involve the (i) Vollhardt cyclization of bis(propargyl)benzenes with bis(trimethylsilyl)acetylene, (ii) halo-desilylation introducing chlorine, bromine, or iodine substituents, and (iii) dehydrogenation. Pd catalysis allows selective functionalization at the anthracenes' east/west positions. A tetrahydropentacene is synthesized and derivatized via the same strategy, employing tetrapropargylbenzene.

ALPHA-CINNAMIDE COMPOUNDS AND COMPOSITIONS AS HDAC8 INHIBITORS

The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

Substituted 5,6,11,12-tetradehydrodibenzo[ a, e ]cyclooctenes: Syntheses, properties, and DFT studies of substituted sondheimer-wong diynes

Highly strained cyclic acetylenes 5,6,11,12-tetradehydrodibenzo[a,e]cyclooctenes (Sondheimer-Wong diynes) having various substituents on their benzene rings were synthesized successfully by one-pot treatment of the corresponding formyl sulfones with diethyl chlorophosphate/lithium hexamethyldisilazide (LiHMDS) and then lithium diisopropylamide (LDA). When mixtures of two types of formyl sulfones bearing different substituents were subjected to this protocol, the unsymmetrically substituted Sondheimer-Wong diynes could be synthesized in a stepwise manner by isolation of the heterocoupled vinyl sulfone intermediates followed by their treatment with LDA. The UV-vis absorption spectra and cyclic voltammograms of the substituted Sondheimer-Wong diynes were recorded. The electronic effect of substituents on the diynes was investigated in their click reactions and nucleophilic and electrophilic additions.