21911-69-3

Basic information

• Product Name: P-TOLYLAMINO-ACETIC ACID
• Synonyms: N-(4-Methylphenyl)glycine;N-(3-methylphenyl)glycine
• CAS NO: 21911-69-3
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.19
• Mol File: 21911-69-3.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 359.8°Cat760mmHg
• Flash Point: 171.4°C
• Appearance: /
• Density: 1.211g/cm³
• Vapor Pressure: 8.35E-06mmHg at 25°C
• CAS DataBase Reference: P-TOLYLAMINO-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: P-TOLYLAMINO-ACETIC ACID(21911-69-3)
• EPA Substance Registry System: P-TOLYLAMINO-ACETIC ACID(21911-69-3)

Safety Data

• Hazardous Substances Data: 21911-69-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11NO2/c1-7-2-4-8(5-3-7)10-6-9(11)12/h2-5,10H,6H2,1H3,(H,11,12)/p-1

Upstream product

• 21911-68-2 ethyl 2-(p-tolylamino)acetate 
• 106-49-0 p-toluidine 
• 79-11-8 chloroacetic acid 
• 99-99-0 1-methyl-4-nitrobenzene 
• 7732-18-5 water 
• 105-36-2 ethyl bromoacetate 
• 16728-84-0 p-tolylaminoacetonitrile 
• 84827-47-4 2-(4-methylphenylamino)acetic acid tert-butyl ester 
• 298-12-4 Glyoxilic acid 
• 106-38-7 para-bromotoluene 

Downstream Products

• 108063-16-7 N-[(2-chloro-4-methyl-phenoxy)-acetyl]-N-p-tolyl-glycine 
• 28444-51-1 2,2'-(p-tolylazanediyl)diacetic acid 
• 101571-27-1 N-[(4-chloro-phenoxy)-acetyl]-N-p-tolyl-glycine 
• 32549-31-8 1-(4-methylphenyl)hydantoin 
• 109598-88-1 N-[(2,4-dichloro-phenoxy)-acetyl]-N-p-tolyl-glycine 
• 52827-02-8 2-(nitroso(p-tolyl)amino)acetic acid 
• 21911-68-2 ethyl 2-(p-tolylamino)acetate 
• 142503-68-2 4-Amino-5-(p-tolylamino-methyl)-2,4-dihydro-[1,2,4]triazole-3-thione 
• 3483-19-0 3-(4-methylphenyl)sydnone 
• 4918-23-4 4-bromo-3-p-tolyl-sydnone 
• 2350-99-4 2-[(4-methylphenyl)amino]acetohydrazide 
• 92516-06-8 5-mercapto-4-phenyl-3-(N-p-tolylamino)methyl-1,2,4-triazole 
• 92515-98-5 4-phenyl-1-(N-p-tolylamino)acetyl thiosemicarbazide 
• 68150-35-6 7-diethylamino-6-methyl-3-p-tolyl-2,2-bis-trifluoromethyl-3,4-dihydro-2H-[1,3]oxazepin-5-one 

Relevant articles and documents

Perovskite as Recyclable Photocatalyst for Annulation Reaction of N-Sulfonyl Ketimines

A sustainable and cost-effective manner for the photocatalytic annulation reaction of N-sulfonyl ketimines with N-arylglycines to synthesize imidazolidine-fused sulfamidates (31 examples) by employing CsPbBr3 as a heterogeneous photocatalyst has been developed. The catalyst CsPbBr3 can be simply recovered from the reaction mixture and reused at least five times without an obvious reduction in its photocatalytic reactivity, exhibiting a high catalyst economic feature.

Discovery and evolution of 12N-substituted aloperine derivatives as anti-SARS-CoV-2 agents through targeting late entry stage

So far, there is still no specific drug against COVID-19. Taking compound 1 with anti-EBOV activity as the lead, fifty-four 12N-substituted aloperine derivatives were synthesized and evaluated for the anti-SARS-CoV-2 activities using pseudotyped virus model. Among them, 8a exhibited the most potential effects against both pseudotyped and authentic SARS-CoV-2, as well as SARS-CoV and MERS-CoV, indicating a broad-spectrum anti-coronavirus profile. The mechanism study disclosed that 8a might block a late stage of viral entry, mainly via inhibiting host cathepsin B activity rather than directly targeting cathepsin B protein. Also, 8a could significantly reduce the release of multiple inflammatory cytokines in a time- and dose-dependent manner, such as IL-6, IL-1β, IL-8 and MCP-1, the major contributors to cytokine storm. Therefore, 8a is a promising agent with the advantages of broad-spectrum anti-coronavirus and anti-cytokine effects, thus worthy of further investigation.

Novel sydnone derivatives carrying azidomethyl-1,2, 4-oxadiazole unit and their 1,3-dipolar cycloadditions

A series of 1,2,4-oxadiazolymethyl sydnones carrying azido group were synthesized and subjected to react with a variety of alkenic and acetylenic dipolarophilic reagents; N-phenyl maleimide, phenyl vinyl sulfone, and phenyl propiolic acid. All the new products are identified by spectral/physical data including high-resolution mass measurements and X-ray diffraction data.