21914-07-8 Usage
General Description
5,5-diphenylbarbituric acid is a chemical compound with the molecular formula C13H10N2O3. It is a derivative of barbituric acid and is commonly used in the synthesis of pharmaceutical drugs. 5,5-diphenylbarbituric acid has sedative and hypnotic properties and is often utilized as an intermediate in the production of barbiturate drugs, which are used as central nervous system depressants. It works by enhancing the activity of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the brain, resulting in a calming effect. 5,5-diphenylbarbituric acid is also used as a reactant in organic synthesis and as a research chemical in the study of barbiturate drugs and their effects on the central nervous system.
Check Digit Verification of cas no
The CAS Registry Mumber 21914-07-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,9,1 and 4 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 21914-07:
(7*2)+(6*1)+(5*9)+(4*1)+(3*4)+(2*0)+(1*7)=88
88 % 10 = 8
So 21914-07-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H12N2O3/c19-13-16(11-7-3-1-4-8-11,12-9-5-2-6-10-12)14(20)18-15(21)17-13/h1-10H,(H2,17,18,19,20,21)
21914-07-8Relevant articles and documents
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McElvain
, p. 1303 (1935)
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The Chemistry of Aryllead(IV) Tricarboxylates. Reaction with Derivatives of Malonic Acid: New Routes to α-Aryl Carboxylic Acids and Arylated Barbituric Acid Derivatives
Kopinski, Richard P.,Pinhey, John T.,Rowe, Bruce A.
, p. 1245 - 1254 (2007/10/02)
Derivatives of 2,2-dimethyl-1,3-dioxan-4,6-dione (Meldrum's acid) and the sodium salts of substituted malonic esters undergo electrophilic C-arylation in high yield with aryllead triacetates, thus providing new routes to α-arylalkanoic acids.Syntheses of the antiflammatory compound 2-(p-isobutylphenyl)propanoic acid (Ibuprofen) have been carried out to demonstrate the method.The arylation reaction has been extended to 5-ethylbarbituric acid and to barbituric acid itself, which affords the 5,5-diarylated derivatives in good yield.A study of the effect of some tertiary bases on the reaction of p-methoxyphenyllead triacetate with the 5-isopropyl derivative of Meldrum's acid has shown that replacement of pyridine by 2,2'-bipyridyl results in an increase in yield and reaction rate, while a further marked improvement occurs in the presence of 1,10-phenanthroline.
