21921-70-0

Basic information

• Product Name: 6-Chloro-1H-quinolin-4-one
• Synonyms: 6-Chloro-1H-quinolin-4-one
• CAS NO: 21921-70-0
• Molecular Formula: C9H6ClNO
• Molecular Weight: 179.60304
• Mol File: 21921-70-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Chloro-1H-quinolin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-1H-quinolin-4-one(21921-70-0)
• EPA Substance Registry System: 6-Chloro-1H-quinolin-4-one(21921-70-0)

Safety Data

• Hazardous Substances Data: 21921-70-0(Hazardous Substances Data)

Usage

General Description

6-chloro-1H-quinolin-4-one is a chemical compound with the molecular formula C9H6ClNO. It is a quinoline derivative and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 6-chloro-1H-quinolin-4-one has also been investigated for its potential use as a precursor in the development of novel materials and organic compounds. The 6-chloro-1H-quinolin-4-one structure contains a chloro substituent on the quinoline ring, which imparts unique properties and reactivity to the molecule. Additionally, this compound has been studied for its biological activities, including its potential as an antibacterial and antifungal agent, making it an important target for further research and development in the field of medicinal chemistry.

Upstream product

• 79607-22-0 6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 
• 25063-46-1 5-(((4-chlorophenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 106-47-8 4-chloro-aniline 
• 53977-19-8 6-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
• 75175-79-0 1-(3-chlorophenyl)-3-dimethylamino-prop-2-en-1-one 

Downstream Products

• 4203-18-3 4,6-dichloroquinoline 

Relevant articles and documents

Structural optimization of quinolon-4(1 H)-imines as dual-stage antimalarials: Toward increased potency and metabolic stability

Discovery of novel effective and safe antimalarials has been traditionally focused on targeting erythrocytic parasite stages that cause clinical symptoms. However, elimination of malaria parasites from the human population will be facilitated by intervent

Direct C-3-alkenylation of quinolones via palladium-catalyzed C-H functionalization

An unprecedented C-3-alkenylation of quinolones was reported through palladium-catalyzed C-H functionalization with 1% catalyst loading. This method provides an efficient route to a variety of new quinolone derivatives.

Use of polyphosphoric acid in the hydrolysis of chromone esters

Hydrolysis of esters was achieved in fairly high yield (59-98%) using polyphosphoric acid (PPA). The reagent was particularly useful for the hydrolysis of chromone side chain esters without ring opening.