21926-01-2

Basic information

• Product Name: 2-Amino-1,5-pentanediol
• Synonyms: 2-Amino-1,5-pentanediol;Glutamidiol;2-Amino-pentane-1,5-diol
• CAS NO: 21926-01-2
• Molecular Formula: C5H13 N O2
• Molecular Weight: 119.1622
• Mol File: 21926-01-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 295.7°Cat760mmHg
• Flash Point: 132.7°C
• Appearance: /
• Density: 1.081g/cm³
• Vapor Pressure: 0.000155mmHg at 25°C
• Refractive Index: 1.488
• CAS DataBase Reference: 2-Amino-1,5-pentanediol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-1,5-pentanediol(21926-01-2)
• EPA Substance Registry System: 2-Amino-1,5-pentanediol(21926-01-2)

Safety Data

• Hazardous Substances Data: 21926-01-2(Hazardous Substances Data)

Usage

Physical properties

white, crystalline solid

Uses

Chelating agent
Corrosion inhibitor
Building block for synthesis of pharmaceuticals and fine chemicals
Component in production of surfactants, metal salts, and lubricants
Ingredient in moisturizers and skin care products in cosmetics and personal care industry.

InChI:InChI=1/C5H13NO2/c6-5(4-8)2-1-3-7/h5,7-8H,1-4,6H2

Upstream product

• 6525-53-7 glutamic acid dimethyl ether 
• 617-65-2 Glutamic acid 

Relevant articles and documents

Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 8. Molecular dissections of carbocyclic 3-deazaadenosine as inhibitors of S-adenosylhomocysteine hydrolase

A series of 9-(hydroxyalkyl)-3-deazaadenines, which are analogues of the carbocyclic derivative of 3-deazaadenosine (3-deaza-C-Adpo), were synthesized. The analogues were tested as inhibitors of bovine liver S-adenosyl-L-homocysteine (AdoHcy) hydrolase (EC 3.3.1.1) and as inhibitors of vaccinia virus (WR) replication in clone 929 mouse L cells and the results were compared to those observed for the parent compound, 3-deaza-C-Ado. 4-Amino-1-(2,3-dihydroxy-1-propyl)imidazo[4,5-c]pyridine (14), the analogue which included the 1'-, 2'- and 3'-carbons of 3-deaza-C-Ado, was the most active inhibitor toward purified AdoHcy hydrolase. The inhibitory effect of 14 (K(i) = 768 nM) on AdoHcy hydrolase was significantly less than that observed for 3-deaza-C-Ado (K(i) = 4 nM). Analogue 14 also exhibited inhibitory activity against vaccinia virus replication, but the activity was less than that observed with 3-deaza-C-Ado. 4-Amino-1-(4-hydroxy-1-butyl)imidazo[4,5-c]pyridine (15) showed little or no inhibitory activity toward AdoHcY hydrolase, but it did exhibit antiviral effects comparable to 14. These results suggest that 3-deaza-C-Ado and analogue 14 may be producing their antiviral effects by altering a critical viral methylation (e.g., methylation of the 5'-cap of viral mRNA), whereas analogue 15 may be acting through an alternative mechanism.