219297-09-3

Basic information

• Product Name: BOC-(S)-3-AMINO-4-(1-NAPHTHYL)-BUTYRIC ACID
• Synonyms: 3-aMino-5-(tert-butoxy)-4-(naphthalen-1-yl)-5-oxopentanoic acid;(S)-b-(Boc-amino)-1-naphthalenebutanoic acid;1-Naphthalenebutanoicacid, |-[[(1,1-dimethylethoxy)carbonyl]amino]-,(bS)-;RARECHEM AK PT B049;N-BETA-T-BUTOXYCARBONYL-L-HOMO(1-NAPHTHYL)ALANINE;N-T-BUTOXYCARBONYL-(S)-3-AMINO-4-(1-NAPHTHYL)BUTANOIC ACID;BOC-(1-NAPHTHYL)-L-BETA-HOMOALANINE;BOC-BETA-HOALA(1-NAPHTHYL)-OH
• CAS NO: 219297-09-3
• Molecular Formula: C19H23NO4
• Molecular Weight: 329.39
• Product Categories: 3-Amino-4-phenylbutyric Acid Analogs;3-Amino-4-phenylbutanoic Acid Analogs;B-Amino
• Mol File: 219297-09-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 527.9 °C at 760 mmHg
• Flash Point: 273.1 °C
• Appearance: /
• Density: 1.179
• Vapor Pressure: 5.65E-12mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: 2-8°C
• CAS DataBase Reference: BOC-(S)-3-AMINO-4-(1-NAPHTHYL)-BUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-(S)-3-AMINO-4-(1-NAPHTHYL)-BUTYRIC ACID(219297-09-3)
• EPA Substance Registry System: BOC-(S)-3-AMINO-4-(1-NAPHTHYL)-BUTYRIC ACID(219297-09-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 219297-09-3(Hazardous Substances Data)

Usage

General Description

BOC-(S)-3-AMINO-4-(1-NAPHTHYL)-BUTYRIC ACID is a chemical compound with the molecular formula C21H23NO4. It is a derivative of the amino acid alanine, with a butyric acid group and a 1-naphthyl group attached to the amino group. BOC-(S)-3-AMINO-4-(1-NAPHTHYL)-BUTYRIC ACID is commonly used as a building block in the synthesis of pharmaceuticals and other biologically active molecules. The BOC group is a protective group for the amino group, which can be removed under mild conditions to reveal the free amine. The presence of the 1-naphthyl group may confer specific biological or chemical properties to the molecule, making it useful in drug discovery and medicinal chemistry research. Overall, BOC-(S)-3-AMINO-4-(1-NAPHTHYL)-BUTYRIC ACID is an important and versatile chemical building block with various potential applications in the field of organic chemistry and drug development.

InChI:InChI=1/C19H23NO4/c1-19(2,3)24-18(23)20-15(12-17(21)22)11-14-9-6-8-13-7-4-5-10-16(13)14/h4-10,15H,11-12H2,1-3H3,(H,20,23)(H,21,22)/t15-/m0/s1

Relevant articles and documents

Synthesis method of chiral N-Boc-3-amino-4-aryl-butyric acid

The invention relates to a synthesis method of chiral N-Boc-3-amino-4-aryl-butyric acid. The method is as below: 1, conducting a cross metathesis reaction, an asymmetric conjugate addition reaction and an oxidation reaction on starting materials including an allyl aromatic compound and crotonaldehyde by a continuous reaction one-pot method to synthesize an N-Boc-3-aryl methyl-5-oxo isoxazole intermediate; or conducting an asymmetric conjugate addition reaction and an oxidation reaction on a starting material (E)-4-aryl-2-crotonaldehyde by a continuous reaction one-pot method to synthesize an N-Boc-3-aryl methyl-5-oxo isoxazole intermediate; and 2, subjecting (3R)-N-Boc-3-aryl methyl-5-oxo isoxazole intermediate by high-pressure hydrogenation to directly prepare the chiral N-Boc-3-amino-4-aryl-butyric acid. The synthesis method provided by the invention has the advantages of simple operation, mild reaction conditions, target product yield reaching 60-69%, and ee value of the target product reaching as high as 96%. The synthetic route has industrialization prospect.