219318-65-7Relevant articles and documents
Synthesis and analgesic activity of 1-(1- piperidinyl)methyl-2-(4-substituted styryl)-5-chlorobenzimidazole derivatives
Cakir, Bilge,Uzunoglu, Sermin,Tosun, Ali Ulvi,Sahin, M. Fethi
, p. 103 - 106 (2007/10/03)
Seven 1-(1-piperidinyl)methyl-2-(4-substituted styryl)-5-chlorobenzimidazole derivatives were synthesized by the reaction of 2-(p-substituted styryl)-5-chlorobenzimidazoles with formaldehyde and piperidine in methanol. Analgesic activity of the 1-(1-piperidinyl)-methyl-2-(4-substituted styryl)-5-chlorobenzimidazole derivatives was investigated by the modified Koster test in mice. No obvious relationships between analgesic activity and the nature of the substituent on the styryl group was found.