21943-15-7 Usage
Description
3,5-Dibromo-2-hydroxypyrazine is a pyrazine derivative characterized by the presence of two bromine atoms at the 3 and 5 positions and a hydroxyl group at the 2 position. It is a white solid with unique chemical properties that make it a valuable building block in chemical synthesis and a versatile agent in various applications.
Uses
Used in Chemical Synthesis:
3,5-Dibromo-2-hydroxypyrazine is used as a potential building block in chemical synthesis for the development of new compounds and materials. Its unique structure allows for the formation of various derivatives, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Heteroaromatic Nucleophilic Substitution:
3,5-Dibromo-2-hydroxypyrazine is utilized in the SRN1 (Substitution Reaction of Nitrogen-centered radicals type 1) mechanism for heteroaromatic nucleophilic substitution. This process is essential in the synthesis of various heteroaromatic compounds, which are widely used in pharmaceuticals, agrochemicals, and materials science.
Used in Pharmaceutical Industry:
3,5-Dibromo-2-hydroxypyrazine is used as an intermediate in the synthesis of pharmaceutical compounds. Its unique structure and reactivity make it a promising candidate for the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
3,5-Dibromo-2-hydroxypyrazine is employed as a key intermediate in the synthesis of agrochemicals, such as pesticides and herbicides. Its versatility in chemical reactions allows for the development of novel and effective agrochemicals to address various agricultural challenges.
Used in Materials Science:
3,5-Dibromo-2-hydroxypyrazine is used in the development of new materials with unique properties. Its ability to form various derivatives makes it a valuable component in the synthesis of advanced materials for applications in electronics, optics, and other high-tech industries.
Check Digit Verification of cas no
The CAS Registry Mumber 21943-15-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,9,4 and 3 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 21943-15:
(7*2)+(6*1)+(5*9)+(4*4)+(3*3)+(2*1)+(1*5)=97
97 % 10 = 7
So 21943-15-7 is a valid CAS Registry Number.
21943-15-7Relevant articles and documents
The complete synthesis of favipiravir from 2-aminopyrazine
Guo, Qi,Xu, Mingshuo,Guo, Shuang,Zhu, Fuqiang,Xie, Yuanchao,Shen, Jingshan
, p. 1043 - 1051 (2019/04/25)
Favipiravir was first synthesized from an inexpensive and commercially available starting material, 2-aminopyrazine. The preferred route embedded within Scheme?4 consisted of seven steps, and was highlighted by the novel and efficient synthesis of 3,6-dichloropyrazine-2-carbonitrile 8. This intermediate was prepared in four successive steps which were regioselective chlorination of the pyrazine ring, bromination, Pd-catalyzed cyanation, and Sandmeyer diazotization/chlorination. This protocol eliminated the hazardous POCl3 of previous synthetic methods and offered a better yield (48%) which was 1.3-fold higher than a recently published procedure. From intermediate 8, the subsequent nucleophilic fluorination, nitrile hydration and hydroxyl substitution efficiently afforded the target product. Another synthetic approach with the same starting material was also investigated to bypass the allergy-causing dichloro intermediate 8. However, the key step of monofluorination at the pyrazine C6 position of intermediate 19 or 22 was not achieved.