21946-71-4

Basic information

• Product Name: (2S)-2-Amino-1,5-pentanediol
• Synonyms: (2S)-2-Amino-1,5-pentanediol;(S)-2-Amino-1,5-pentanediol;(S)-2-aminopentane-1,5-diol HCl
• CAS NO: 21946-71-4
• Molecular Formula: C₅H₁₃NO₂
• Molecular Weight: 119.16
• Mol File: 21946-71-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 125-130 °C(Press: 0.1 Torr)
• Appearance: /
• Density: 1.081±0.06 g/cm3(Predicted)
• PKA: 12.79±0.10(Predicted)
• CAS DataBase Reference: (2S)-2-Amino-1,5-pentanediol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-Amino-1,5-pentanediol(21946-71-4)
• EPA Substance Registry System: (2S)-2-Amino-1,5-pentanediol(21946-71-4)

Safety Data

• Hazardous Substances Data: 21946-71-4(Hazardous Substances Data)

Upstream product

• 16450-41-2 L-glutamic acid diethyl ester 
• 1118-89-4 diethyl-L-glutamate hydrochloride 
• 6525-53-7 L-glutamic acid dimethyl ester 
• 196937-34-5 (2S)-[(2-hydroxy-(1R)-phenyl)ethylamino]pentan-1,5-diol 
• 56-86-0 L-glutamic acid 
• 60-29-7 diethyl ether 
• 62024-36-6 5-chloro-4-oxopentanoic acid methyl ester 
• 171561-60-7 3-(6-oxo-5R-phenyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)propanoic acid methyl ester 
• 171561-58-3 (-)-4-oxo-5-[(R)-(phenyl)(phenylmethoxycarbonylamino)acetoxy]pentanoic acid methyl ester 
• 171753-91-6 (-)-3-[(3S,5R)-6-oxo-5-phenylmorpholin-3-yl]propanoic acid methyl ester 
• 478646-26-3 (2S)-benzyl 1,5-dihydroxypentan-2-ylcarbamate 

Downstream Products

• 129049-06-5 (S)-2-(2-hydroxybenzylideneamino)-1,5-pentanediol 
• 23356-92-5 (S)-2-(Benzolsulfon-amido)-1,5-diacetyl-mercapto-pentan 

Relevant articles and documents

A preparation method of fumagillin amino alcohol

The invention discloses a preparation method of fumagillin amino alcohol shown as a formula I in the specification. The method comprises the following steps: (1) reducing amino acid shown in a formulaII to obtain a compound shown in a formula III; and (2) carrying out an ammonium salt synthesis reaction on fumagillin and the compound shown in the formula III to obtain fumagillin amino alcohol. The preparation method is short in reaction route and high in synthesis efficiency, the separation and purification steps are reduced, and mass production can be achieved. Meanwhile, the synthesized fumagillin amino alcohol is low in toxicity, can be dissolved and degraded in nature and is good in water solubility.

NOVEL BICYCLIC COMPOUNDS

The invention is concerned with novel bicyclic compounds of formula (I), wherein A, L, E, F, G, R1, R2, R3, R4, R5, R6, R7, V, W and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR2 receptor, CCR5 receptor and/or CCR3 receptor and can be used as medicaments.

A general synthesis of enantiopure 1,2-aminoalcohols via chiral morpholinones

Eleven optically active 1,2-aminoalcohols 20a-i and 26b-c were prepared from D-phenylglycine via cyclic imines 7b-i (or enamine 7a). The key step of the strategy is the diastereoselective reduction of chiral oxazinones 7a-i.