219500-45-5 Usage
Description
(-)-(S)-2-bromo-3-phenylpropan-1-ol, also known as S-Bromo-α-phenylpropan-1-ol, is a chiral chemical compound with the molecular formula C9H11BrO. It exists in two enantiomeric forms, (S)and (R)-, with the S enantiomer being the more commonly used. This colorless to pale yellow liquid possesses a slightly sweet, floral odor.
Uses
Used in Pharmaceutical Synthesis:
(-)-(S)-2-bromo-3-phenylpropan-1-ol is used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Its unique structure and properties make it a valuable component in the development of new drugs.
Used in Antimicrobial and Antifungal Applications:
(-)-(S)-2-bromo-3-phenylpropan-1-ol has been studied for its antimicrobial and antifungal properties, indicating its potential use in the development of new drugs to combat infections and fungal growth.
Used as a Chiral Resolving Agent:
(-)-(S)-2-bromo-3-phenylpropan-1-ol is utilized as a chiral resolving agent, which is essential in the separation of enantiomers, a critical process in the production of pure pharmaceutical compounds.
Used in Synthesis of Chiral Ligands:
Additionally, it serves as a precursor in the synthesis of chiral ligands for asymmetric syntheses, a key technique in creating enantiomerically pure compounds, which is particularly important in the pharmaceutical industry where the desired biological activity often resides in just one enantiomer.
Check Digit Verification of cas no
The CAS Registry Mumber 219500-45-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,9,5,0 and 0 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 219500-45:
(8*2)+(7*1)+(6*9)+(5*5)+(4*0)+(3*0)+(2*4)+(1*5)=115
115 % 10 = 5
So 219500-45-5 is a valid CAS Registry Number.
219500-45-5Relevant articles and documents
Development of Ketone-Based Brominating Agents (KBA) for the Practical Asymmetric α-Bromination of Aldehydes Catalyzed by Tritylpyrrolidine
Kano, Taichi,Maruoka, Keiji,Shimogaki, Mio,Takeshima, Aika
, p. 5959 - 5963 (2020/07/04)
Ketone-based brominating agents (KBA), ortho-substituted 2,2,2-tribromoacetophenones, have been developed, and the highly enantioselective and practical α-bromination of aldehydes with KBA was achieved. The reaction could be performed in the presence of only 0.1-1 mol % of catalyst without using a halogenated solvent at 0 °C and was found to be scalable.
α-amination of aldehydes catalyzed by in situ generated hypoiodite
Tian, Jie-Sheng,Ng, Kang Wai Jeffrey,Wong, Jiun-Ru,Loh, Teck-Peng
supporting information, p. 9105 - 9109 (2012/10/29)
The metal-free amination of different aldehydes is catalyzed by hypoiodite, which is generated by employing commercially available sodium percarbonate as the co-oxidant. This approach has several advantages: it is a metal-free oxidation that works under m
Extractive biocatalysis: A powerful tool in selectivity control in yeast biotransformations
D'Arrigo, Paola,Fuganti, Claudio,Pedrocchi Fantoni, Giuseppe,Servi, Stefano
, p. 15017 - 15026 (2007/10/03)
The effect of absorbing resins on the yeast reduction of α,β- unsaturated carbonyl compounds is reported. Enantioselectivity, chemoselectivity and space-time yields of the biotransformation are impressively enhanced. The distribution of substrates and products between the resin and the water phase shows that the improved selectivity has to be attributed to the control of substrate concentration.
