219506-21-5

Basic information

• Product Name: (S)-2-Benzyloxycarbonylamino-4-[methoxy-(2-methoxycarbonyl-butyl)-phosphinoyl]-butyric acid methyl ester
• Synonyms: (S)-2-Benzyloxycarbonylamino-4-[methoxy-(2-methoxycarbonyl-butyl)-phosphinoyl]-butyric acid methyl ester
• CAS NO: 219506-21-5
• Molecular Weight: 443.434
• Mol File: 219506-21-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-2-Benzyloxycarbonylamino-4-[methoxy-(2-methoxycarbonyl-butyl)-phosphinoyl]-butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Benzyloxycarbonylamino-4-[methoxy-(2-methoxycarbonyl-butyl)-phosphinoyl]-butyric acid methyl ester(219506-21-5)
• EPA Substance Registry System: (S)-2-Benzyloxycarbonylamino-4-[methoxy-(2-methoxycarbonyl-butyl)-phosphinoyl]-butyric acid methyl ester(219506-21-5)

Safety Data

• Hazardous Substances Data: 219506-21-5(Hazardous Substances Data)

Upstream product

• 179638-15-4 2-(Diethoxymethyl-ethoxy-phosphinoylmethyl)-butyric acid ethyl ester 
• 219507-12-7 2-Hydroxyphosphinoylmethyl-butyric acid 
• 3070-65-3 ethyl 2-methylenebutyrate 
• 75266-40-9 N-benzyloxycarbonyl-L-α-vinylglycine methyl ester 
• 179638-16-5 2-Methoxyphosphinoylmethyl-butyric acid methyl ester 

Relevant articles and documents

Mechanism-based inactivation of E. coli γ-glutamylcysteine synthetase by phosphinic acid- and sulfoximine-based transition-state analogues

Phosphinic acid- and sulfoximine-based transition state analogues having a carboxyl group at the β-carbon to the hetero atom exhibited significantly higher potency as mechanism-based inhibitors of E. coli γ-glutamylcysteine synthetase as compared with L-buthionine-SR-sulfoximine. The enhanced inhibition potency is evidenced by both tight binding of the inhibitor and slow enzyme reactivation.