219544-54-4

Basic information

• Product Name: 3-<1-(4-chlorobenzyl)indol-3-yl>propionic acid
• Synonyms: 3-<1-(4-chlorobenzyl)indol-3-yl>propionic acid
• CAS NO: 219544-54-4
• Molecular Weight: 313.784
• Mol File: 219544-54-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-<1-(4-chlorobenzyl)indol-3-yl>propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-<1-(4-chlorobenzyl)indol-3-yl>propionic acid(219544-54-4)
• EPA Substance Registry System: 3-<1-(4-chlorobenzyl)indol-3-yl>propionic acid(219544-54-4)

Safety Data

• Hazardous Substances Data: 219544-54-4(Hazardous Substances Data)

Upstream product

• 830-96-6 Indole-3-propionic acid 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 40641-03-0 ethyl 3-(indol-3-yl)propanoate 
• 405275-43-6 3-[1-(4-chloro-benzyl)-1H-indol-3-yl]-propionic acid ethyl ester 

Downstream Products

• 1246747-51-2 C₂₅H₂₀ClN₃O 
• 1246747-50-1 C₂₄H₂₁ClN₂O 
• 1246747-53-4 3-[1-(4-chlorobenzyl)-1H-indol-3-yl]-N-(4-nitrophenyl)propanamide 
• 1246747-52-3 C₂₅H₂₀ClF₃N₂O 
• 1246747-47-6 C₂₇H₂₂ClN₃O 
• 1246747-46-5 C₂₇H₂₂ClN₃O 
• 1246747-49-8 C₂₇H₂₂ClN₃O 
• 1246747-48-7 C₂₇H₂₂ClN₃O 
• 1246747-45-4 C₂₃H₂₀ClN₃O 
• 1246747-44-3 C₂₃H₂₀ClN₃O 

Relevant articles and documents

Synthetic N-pyridinyl(methyl)-indol-3-ylpropanamides as new potential immunosuppressive agents

Several N-pyridinyl(methyl)-indol-3-ylpropanamides were synthesized and pharmacological evaluations of their immunosuppressive potential were performed. Among thirteen compounds tested in vitro on murine T proliferation, three showed interesting inhibitin

New N-pyridinyl(methyl)-indolalkanamides acting as topical inflammation inhibitors

The authors have described the synthetic way to new N-pyridinyl(methyl) indolylpropanamides acting as non acidic NSAIDs. Pharmacomodulation was carried out at N-1 and C-5 of the indole ring and at the level of the propanamide chain. N-(pyridin-3-ylmethyl)-3-[5-chloro-1-(4-chlorobenzyl)-indol-3-yl]propanamide 32 represents one of the most potent compounds evaluated in the TPA-induced mouse ear swelling assay, with a level of activity higher than that of ibuprofen and comparable to that of dexamethasone.