219565-74-9

Basic information

• Product Name: dihydrohonokiol
• Synonyms: dihydrohonokiol
• CAS NO: 219565-74-9
• Molecular Formula: C18H20O2
• Molecular Weight: 268.35
• Mol File: 219565-74-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: dihydrohonokiol(CAS DataBase Reference)
• NIST Chemistry Reference: dihydrohonokiol(219565-74-9)
• EPA Substance Registry System: dihydrohonokiol(219565-74-9)

Safety Data

• Hazardous Substances Data: 219565-74-9(Hazardous Substances Data)

Upstream product

• 329717-61-5 3-allyl-2'-methoxy-5'-propyl-biphenyl-4-ol 
• 1355484-75-1 C₁₆H₁₈O₂ 
• 140-67-0 Estragole 
• 89-55-4 5-bromosalicyclic acid 
• 35354-74-6 Honokiol 
• 4068-76-2 5-bromo-2-hydroxy-benzoic acid methyl ester 
• 29415-97-2 methyl 3-bromo-4-hydroxybenzoate 
• 711012-15-6 [5'-(tert-butyl-dimethyl-silanyloxymethyl)-4,2'-bis-methoxymethoxy-biphenyl-3-yl]-methanol 
• 711012-09-8 5'-(tert-butyl-dimethyl-silanyloxymethyl)-4,2'-bis-methoxymethoxy-biphenyl-3-carboxylic acid methyl ester 
• 711012-14-5 5,3'-diallyl-2,4'-bis-methoxymethoxy-biphenyl 
• 711012-13-4 (3'-hydroxymethyl-6,4'-bis-methoxymethoxy-biphenyl-3-yl)-methanol 
• 711012-16-7 5,3'-bis-bromomethyl-2,4'-bis-methoxymethoxy-biphenyl 
• 711012-10-1 2-methoxymethoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid methyl ester 
• 99-96-7 4-hydroxy-benzoic acid 

Relevant articles and documents

METHOD OF PRODUCING BIPHENOLIC COMPOUND, NOVEL BIPHENYL COMPOUND AND SYNTHESIS METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR TREATING PARKINSON'S DISEASE

A method of producing honokiol and analogues thereof, and novel intermediates prepared by virtue thereof are disclosed herein. A pharmaceutical composition for treating Parkinson's disease, which contains honokiol and/or the analogues thereof, is also disclosed herein.

Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan

Honokiol, a biphenyl-type neolignan, which shows the remarkable neurotrophic effect in primary cultured rat cortical neurons, has been effectively synthesized in 21% yield over 14 steps starting from 5-bromosalicylic acid and p-hydroxybenzoic acid by utilizing Pd-catalyzed Suzuki-Miyaura coupling reaction as a key step. Additionally, the structure-activity relationship between neurite outgrowth-promoting activity and its O-methylated and/or its hydrogenated analogues was examined in the primary cultures of fetal rat cortical neurons, suggesting that 5-allyl and 4′-hydroxyl groups are essential for affecting the neurotrophic activity of honokiol.