219638-16-1

Basic information

• Product Name: 2-acetylamino-2-(5-benzyloxy-pyridin-2-ylmethyl)-malonic acid diethyl ester
• Synonyms: 2-acetylamino-2-(5-benzyloxy-pyridin-2-ylmethyl)-malonic acid diethyl ester
• CAS NO: 219638-16-1
• Molecular Weight: 414.458
• Mol File: 219638-16-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-acetylamino-2-(5-benzyloxy-pyridin-2-ylmethyl)-malonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-acetylamino-2-(5-benzyloxy-pyridin-2-ylmethyl)-malonic acid diethyl ester(219638-16-1)
• EPA Substance Registry System: 2-acetylamino-2-(5-benzyloxy-pyridin-2-ylmethyl)-malonic acid diethyl ester(219638-16-1)

Safety Data

• Hazardous Substances Data: 219638-16-1(Hazardous Substances Data)

Upstream product

• 127590-90-3 3-(benzyloxy)-6-(chloromethyl)pyridine 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 

Downstream Products

• 269732-13-0 3-(5-benzyloxy-pyridin-2-yl)-2-tert-butoxycarbonylamino-propionic acid benzyl ester 
• 219638-18-3 ((±)-3-(5-(benzyloxy)pyridine-2-yl)-2-(tert-butoxycarbonylamino)propanoic acid) 
• 219638-17-2 2-amino-3-(5-benzyloxy-pyridin-2-yl)-propionic acid 

Relevant articles and documents

Selective cytotoxicity of azatyrosinamides against ras-transformed NIH 3T3 cells

This study aims to develop novel azatyrosinamide compounds structurally modified from ras-specific antioncogenic azatyrosine. Analogues 4-15 were prepared and their inhibition on the growth of wild-type and ras-transformed NIH 3T3 cell lines was compared. Compound 12 was found to be the most active with IC50 16.5 ± 2.2 μM which is 458-fold more potent than that of azatyrosine. The selective toxicity, defined as IC 50 wild-type/IC50 ras-transformed for this compound was 138.5.