219727-28-3

Basic information

• Product Name: 4-Allyl-2-chloropyridine
• Synonyms: 4-ALLYL-2-CHLOROPYRIDINE;2-Chloro-4-(2-propenyl)-pyridine;2-chloro-4-prop-2-enylpyridine
• CAS NO: 219727-28-3
• Molecular Formula: C8H8ClN
• Molecular Weight: 153.61
• Mol File: 219727-28-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 225 °C
• Flash Point: 112 °C
• Appearance: /
• Density: 1.104
• Vapor Pressure: 0.131mmHg at 25°C
• Refractive Index: 1.533
• CAS DataBase Reference: 4-Allyl-2-chloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Allyl-2-chloropyridine(219727-28-3)
• EPA Substance Registry System: 4-Allyl-2-chloropyridine(219727-28-3)

Safety Data

• Hazardous Substances Data: 219727-28-3(Hazardous Substances Data)

Usage

General Description

4-Allyl-2-chloropyridine is a chemical compound with the molecular formula C7H7ClN. It is a clear, colorless to yellow liquid with a pungent odor and is insoluble in water. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is also used in the production of dyes, rubber chemicals, and other organic compounds. 4-Allyl-2-chloropyridine is considered to be a hazardous chemical and is flammable, and may cause skin and eye irritation upon contact. It is important to handle and store this compound with proper safety precautions in place.

InChI:InChI=1/C8H8ClN/c1-2-3-7-4-5-10-8(9)6-7/h2,4-6H,1,3H2

Upstream product

• 153034-86-7 2-chloro-4-iodopyridine 
• 106-95-6 allyl bromide 
• 73583-37-6 2-chloro-4-bromopyridine 
• 24850-33-7 allyltributylstanane 

Relevant articles and documents

AMINO-PYRIDINE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS

The invention provides certain amino-pyridine-containing compounds of the Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein R3, R4, R5, R6, and the subscript n are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.

Preparation of highly functionalized pyridylmagnesium reagents for the synthesis of polyfunctional pyridines

Functionalized iodopyridines bearing either a chloride, ester or nitrile function were converted to the corresponding organomagnesium derivatives at -40°C or -78°C by treatment with i-PrMgBr (1.1 equiv, 0.5 h, > 90% yield). The resulting functionalized Grignard reagents react with aldehydes, TosCN directly or with allylic bromides and benzoyl chloride after transmetalation with CuCN leading to polyfunctional pyridines.