219872-85-2

Basic information

• Product Name: (αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide
• Synonyms: (αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide;Isavuconazole Impuirty H
• CAS NO: 219872-85-2
• Molecular Formula: C₁₃H₁₄F₂N₄O₂
• Molecular Weight: 296.2726664
• Mol File: 219872-85-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide(CAS DataBase Reference)
• NIST Chemistry Reference: (αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide(219872-85-2)
• EPA Substance Registry System: (αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide(219872-85-2)

Safety Data

• Hazardous Substances Data: 219872-85-2(Hazardous Substances Data)

Usage

Description

(αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide is a chiral compound characterized by its specific stereochemistry, with both the α and β positions being in the R configuration. It features a 2,4-difluorophenyl group attached to a β-hydroxy-α-methyl-1H-1,2,4-triazole core, which is further connected to a butanamide group. This complex structure endows it with unique chemical properties, making it a valuable component in the synthesis of pharmaceuticals and agrochemicals.
Used in Pharmaceutical Industry:
(αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide is used as an intermediate in the synthesis of triazole antifungal agents for the treatment of various fungal infections. Its unique structure allows for the development of potent and selective antifungal drugs that can target specific fungal enzymes or pathways, leading to effective treatment with minimal side effects.
Used in Agrochemical Industry:
(αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide is also used as a key component in the preparation of triazole-based fungicides for agricultural applications. These fungicides are designed to protect crops from a wide range of fungal diseases, ensuring higher yields and better quality produce. The chiral nature of this compound allows for the development of highly effective and environmentally friendly agrochemicals.
Chemical Properties:
(αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide is a white solid, indicating its stability and suitability for use in various chemical reactions and formulations. Its solid-state properties make it easier to handle, store, and incorporate into pharmaceutical and agrochemical products.

Upstream product

• 170862-36-9 (2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile 
• 166948-49-8 (2R,3R)-3-[3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-3-(1H-1,2,4-triazol-1-yl)]butanoic acid 
• 86404-63-9 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone 

Downstream Products

• 219872-86-3 propyl (2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanoate 
• 170862-36-9 (2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile 

Relevant articles and documents

AN IMPROVED PROCESS FOR THE PREPARATION OF TRIAZOLE DERIVATIVES

The present invention relates to an improved process for the preparation of triazole derivatives such as ravuconazole and isavuconazole.