219897-36-6Relevant articles and documents
A new approach to the enantioseparation of Betti bases
Alfonsov, Vladimir A.,Metlushka, Kirill E.,McKenna, Charles E.,Kashemirov, Boris A.,Kataeva, Olga N.,Zheltukhin, Viktor F.,Sadkova, Dilyara N.,Dobrynin, Alexey B.
, p. 488 - 490 (2007)
An improved method for enantioseparation of racemic 1-(α-aminobenzyl) -2-naphthols has been developed by the reaction in situ of Betti base product mixtures with L-(+)-tartaric acid taken in a 1:1 ratio. The products of this reaction are (-)-1-(α-aminobenzyl)-2-naphthol tartrate, the acetal of benzaldehyde and tartaric acid as well as (+)-1,3-diaryl-2,3-dihydro-1H- naphth[1,2-e][1,3]oxazine, which can be easily separated by crystallization. Georg Thieme Verlag Stuttgart.
Acid promoted CIDT for the deracemization of dihydrocinnamic aldehydes with Betti's base
Rosini, Goffredo,Paolucci, Claudio,Boschi, Francesca,Marotta, Emanuela,Righi, Paolo,Tozzi, Francesco
scheme or table, p. 1747 - 1757 (2011/02/28)
Racemic α-epimerizable and unfunctionalized aldehydes have been converted into enantiomerically enriched mixtures through a sequence of (i) a conversion into the diastereoisomeric 3-substituted 1-phenyl-2,3-dihydro-1H- naphtho[1,2-e][1,3]oxazines by reaction with the (R)- or (S)-1-(α- aminobenzyl)-2-naphthol (Betti's base), (ii) an acid promoted crystallization-induced diastereoisomer transformation (CIDT), and (iii) a clean cleavage of the dihydro-1,3-naphthoxazinic ring of the enriched diastereoisomer, easily collected by filtration, allowing the recovery of the enantiomerically enriched aldehydes and the chiral auxiliary.
An efficient kinetic resolution of racemic betti base based on an enantioselective N,O-deketalization
Dong, Yanmei,Li, Rui,Lu, Jun,Xu, Xuenong,Wang, Xinyan,Hu, Yuefei
, p. 8617 - 8620 (2007/10/03)
An efficient kinetic resolution of racemic Betti base with L-(+)-tartaric acid in acetone was developed based on a novel enantioselective N,O-deketalization, by which the enantiopure R- and S-enantiomers of Betti base were obtained as the corresponding N,