220000-86-2 Usage
Description
4-Chloropyridine-2-carboxylic acid tert-butyl ester is an organic compound that serves as an intermediate in the synthesis of various pharmaceuticals and chemical compounds. It is characterized by the presence of a chlorinated pyridine ring and a tert-butyl ester group, which contribute to its reactivity and stability in chemical reactions.
Uses
Used in Pharmaceutical Industry:
4-Chloropyridine-2-carboxylic acid tert-butyl ester is used as a synthetic intermediate for the preparation of 2-aminobenzimidazoles, which are Raf kinase inhibitors. These inhibitors play a crucial role in the development of targeted therapies for the treatment of various cancers by modulating the Raf/MEK/ERK signaling pathway, which is often dysregulated in tumor cells.
Additionally, 4-Chloropyridine-2-carboxylic acid tert-butyl ester can be utilized in the synthesis of other bioactive molecules and pharmaceutical agents, making it a valuable compound in the field of medicinal chemistry and drug discovery. Its versatility in chemical reactions and compatibility with various synthetic routes make it a promising building block for the development of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 220000-86-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,0,0 and 0 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 220000-86:
(8*2)+(7*2)+(6*0)+(5*0)+(4*0)+(3*0)+(2*8)+(1*6)=52
52 % 10 = 2
So 220000-86-2 is a valid CAS Registry Number.
220000-86-2Relevant articles and documents
PREPARATION AND USE OF MOLECULAR SITE TARGETED AND ACTIVATED KINASE INHIBITOR
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Paragraph 0081-0082, (2019/12/12)
Disclosed are molecularly targeted and activated kinase inhibitors and use thereof. Specifically, a compound represented by the following formula A or a pharmaceutically acceptable salt thereof, wherein X is a polar and a non-polar uncharged amino acid such as alanine, proline or threonine; A is alanine; N is asparagine; PABC is -NH-phenyl-CH2-O-; and Z is a drug molecule; wherein the lactobionic acid residue, XAN and PABC are linked to each other by an amide bond; PABC is bonded to Z by an ester group, i.e., -OC(O)-. ????????Lacto-XAN-PABC-Z?????(Formula A)
PREPARATION METHOD OF FLUORO-SUBSTITUTED DEUTERATED DIPHENYLUREA
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Paragraph 0176; 1077; 0178, (2013/03/26)
A fluoro-substituted deuterated diphenylurea compound, especially 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-2-(N-(methyl-d3))picolinamide, preparing method and use for treating or preventing tumor and relative diseases thereof.
SORAFENIB DERIVATIVES AS sEH INHIBITORS
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Page/Page column 49, (2012/09/10)
The present invention provides compounds for the inhibition of soluble epoxide hydrolase and associated disease conditions.
