220034-64-0

Basic information

• Product Name: 7-(3,5-dibromo-4-hydroxyphenethylamino)-1-tosyl-3,4-dihydropyrrolo[4,3,2-de]quinolin-8(1H)-one
• Synonyms: 7-(3,5-dibromo-4-hydroxyphenethylamino)-1-tosyl-3,4-dihydropyrrolo[4,3,2-de]quinolin-8(1H)-one
• CAS NO: 220034-64-0
• Molecular Weight: 619.333
• Mol File: 220034-64-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7-(3,5-dibromo-4-hydroxyphenethylamino)-1-tosyl-3,4-dihydropyrrolo[4,3,2-de]quinolin-8(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(3,5-dibromo-4-hydroxyphenethylamino)-1-tosyl-3,4-dihydropyrrolo[4,3,2-de]quinolin-8(1H)-one(220034-64-0)
• EPA Substance Registry System: 7-(3,5-dibromo-4-hydroxyphenethylamino)-1-tosyl-3,4-dihydropyrrolo[4,3,2-de]quinolin-8(1H)-one(220034-64-0)

Safety Data

• Hazardous Substances Data: 220034-64-0(Hazardous Substances Data)

Upstream product

• 234757-43-8 Ethyl 6,7-dimethoxyindole-3-glyoxylate 
• 203307-89-5 3-(2-Azidoethyl)-6,7-dimethoxyindole 
• 153718-70-8 3-(2-Azidoethyl)-6,7-dimethoxy-1-<(4-methylphenyl)sulfonyl>indole 
• 153718-67-3 3-(2-hydroxyethyl)-6,7-dimethoxyindole 
• 220034-63-9 {2-[7-Hydroxy-6-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-ethyl}-carbamic acid tert-butyl ester 
• 220034-73-1 [2-(7-Benzyloxy-6-methoxy-1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester 
• 220034-60-6 (E)-4-(2-Benzyloxy-6-iodo-3-methoxy-phenylamino)-but-2-enenitrile 
• 220034-61-7 (7-Benzyloxy-6-methoxy-1H-indol-3-yl)-acetonitrile 
• 220034-72-0 2-Benzyloxy-6-iodo-3-methoxy-phenylamine 
• 100245-10-1 2-Benzyloxy-1-methoxy-3-nitro-benzene 
• 70978-05-1 3-methoxy-2-(benzyloxy)benzenamine 
• 15969-08-1 6-methoxy-2-nitrophenol 
• 134755-34-3 3,5-dibromo-4-hydroxy-β-phenethylamine 
• 153718-76-4 7-Methoxy-1-<(4-methylphenyl)sulfonyl>-3,4-dihydropyrrolo<4,3,2-de>quinolin-8(1H)-one 

Downstream Products

• 137022-91-4 7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one 
• 105372-81-4 discorhabdin C 
• 220034-67-3 N-tosyldiscorhabdin C 

Relevant articles and documents

Analogs of the marine alkaloid makaluvamines: Synthesis, topoisomerase II inhibition, and anticancer activity

Twelve analogs of makaluvamines have been synthesized. These compounds were evaluated for their ability to inhibit the enzyme topoisomerase II. Five compounds were shown to inhibit topoisomerase catalytic activity comparable to two known topoisomerase II

A biomimetic approach to the discorhabdin alkaloids: Total syntheses of discorhabdins C and E and dethiadiscorhabdin D

The characteristic spirodienone structure of the discorhabdin alkaloids is readily formed by reaction of the tyramine-substituted indoloquinonimines 26, 35, and 36 with cupric chloride, triethylamine, and oxygen. This cyclization provides a possibly biomimetic route to discorhabdins C and E (41 and 42). The unbrominated spirodienone 40 reacts with hydrogen over Pd/C to give enone 46. Bromination at the α position gives a mixture of bromoenones that undergo smooth conversion to dethiadiscorhabdin D (4) upon treatment with basic alumina.