220041-42-9

Basic information

• Product Name: tert-butyl 2-chloropyrimidine-4-carboxylate
• Synonyms: tert-butyl 2-chloropyrimidine-4-carboxylate
• CAS NO: 220041-42-9
• Molecular Weight: 214.652
• Mol File: 220041-42-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: tert-butyl 2-chloropyrimidine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-chloropyrimidine-4-carboxylate(220041-42-9)
• EPA Substance Registry System: tert-butyl 2-chloropyrimidine-4-carboxylate(220041-42-9)

Safety Data

• Hazardous Substances Data: 220041-42-9(Hazardous Substances Data)

Upstream product

• 149849-92-3 2‐chloropyrimidine‐4‐carboxylic acid 
• 75-65-0 tert-butyl alcohol 
• 220041-41-8 2-Chloro-6-propylthio-4-pyrimidinecarboxylic acid, (1,1-dimethylethyl) ester 
• 7440-02-0 nickel 

Downstream Products

• 1346555-42-7 (R)-tert-butyl 2-(4-benzyl-2-methylpiperazin-1-yl)pyrimidine-4-carboxylate 
• 1346555-41-6 (R)-tert-butyl 2-(2-methyl-4-(4-(methylsulfonyl)phenyl)piperazin-1-yl)pyrimidine-4-carboxylate 

Relevant articles and documents

Imidazotriazine and imidazodiazine compounds

The present invention provides thiazole compounds of Formula I wherein X, Y, Z, X1, X2, X3, X4, X5, R1, R2, R4, R5, R6, R7, and W, are

PICOLINAMIDE AND PYRIMIDINE-4-CARBOXAMIDE COMPOUNDS, PROCESS FOR PREPARING AND PHAMACEUTICAL COMPOSITION COMPRISING THE SAME

Provided are picolinamide and pyrimidine-4-carboxamide compounds, a method for preparing the same, a pharmaceutical composition containing the same, and a medical use using the compound as an agent for preventing, regulating, and treating diseases related to regulation of glucocorticoids by using selective inhibitory activity of the compound for an 11β-HSD1 enzyme. The picolinamide and pyrimidine-4-carboxamide compounds of the present invention are selective inhibitors of human-derived 11β-HSD1 enzymes, and are useful in an agent for preventing, regulating, and treating diseases related to glucocorticoid regulation in which human- derived 11β-HSD1 enzymes are involved, for example, metabolic syndromes such as, type 1 and type 2 diabetes, diabetes later complications, latent autoimmune diabetes adult (LAD A), insulin tolerance syndromes, obesity, impaired glucose tolerane (IGT), impaired fasting glucose (IFG), damaged glucose tolerance, dyslipidemia, atherosclerosis, hypertension, etc.