22020-72-0

Basic information

• Product Name: 3,4,5-Triphenylisoxazole
• Synonyms: 3,4,5-Triphenylisoxazole
• CAS NO: 22020-72-0
• Molecular Formula: C₂₁H₁₅NO
• Molecular Weight: 297.35
• Mol File: 22020-72-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 410.5°C at 760 mmHg
• Flash Point: 109.5°C
• Appearance: /
• Density: 1.137g/cm³
• Vapor Pressure: 1.42E-06mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: 3,4,5-Triphenylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5-Triphenylisoxazole(22020-72-0)
• EPA Substance Registry System: 3,4,5-Triphenylisoxazole(22020-72-0)

Safety Data

• Hazardous Substances Data: 22020-72-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C21H15NO/c1-4-10-16(11-5-1)19-20(17-12-6-2-7-13-17)22-23-21(19)18-14-8-3-9-15-18/h1-15H

Upstream product

• 873-67-6 benzonitrile oxide 
• 1215-07-2 (E)-(1-nitroethene-1,2-diyl)dibenzene 
• 622-42-4 1-nitro-1-phenylmethane 
• 15341-31-8 α-nitro-stilbene 
• 103161-67-7 2-benzoyl-1,2,3-triphenyl-propane-1,3-dione 
• 5452-30-2 3,4,5-triphenyl-4,5-dihydroisoxazole 2-oxide 
• 13286-95-8 meso-1,2-dinitro-1,2-diphenylethane 
• 100-52-7 benzaldehyde 
• 64-19-7 acetic acid 
• 17669-25-9 cis-4,5-dihydro-3,4,5-triphenylisoxazole 
• 65642-46-8 4-bromo-3,5,5-triphenyl-4,5-dihydro-isoxazole 
• 74048-22-9 3-nitro-1,2,3-triphenyl-2-propene-1-one 
• 7512-68-7 1,2,3-triphenyl-propenone oxime 
• 84940-63-6 triphenylisoxazoline-N-oxide 

Downstream Products

• 103-30-0 (E)-1,2-diphenyl-ethene 
• 854869-26-4 3-amino-1,2,3-triphenyl-propenone 
• 6624-55-1 benzil-mono-(O-benzoyl oxime ) 
• 80949-42-4 4-Chloro-5-methoxy-3,4,5-triphenyl-4,5-dihydro-isoxazole 
• 6237-59-8 hexamethyl benzenehexacarboxylate 
• 58329-12-7 dimethyl 2,5,6-triphenylpyridine-3,4-dicarboxylate 
• 80949-37-7 4-Chloro-3,4,5-triphenyl-4,5-dihydro-isoxazol-5-ol 
• 588-59-0 stilbene 
• 62-23-7 4-nitro-benzoic acid 
• 65-85-0 benzoic acid 
• 144-62-7 oxalic acid 
• 4888-39-5 1,2,3-triphenylpropane-1,3-dione 

Relevant articles and documents

A One Step Transformation of the Sodium Salt of α-aci-Nitrotoluene into 3,4,5-Triphenylisoxazole

3,4,5-Triphenylisoxazole was produced by the reaction of the sodium salt of α-aci-nitrotoluene with the 1-cyano-1-methylethyl radical.The reaction was found to proceed via one electron transfer from α-aci-nitrotoluene anion to a 1-cyano-1-methylethyl radi

Synthesis of 3,5-Disubstituted Isoxazoles through a 1,3-Dipolar Cycloaddition Reaction between Alkynes and Nitrile Oxides Generated from O-Silylated Hydroxamic Acids

In this paper, we report the regioselective synthesis of 3,5-disubstituted isoxazoles by 1,3-dipolar cycloaddition between alkynyl dipolarophiles and nitrile oxide dipoles generated in-situ from O-silylated hydroxamic acids in the presence of trifluoromethanesulfonic anhydride and NEt3. Thanks to the mild, metal-free and oxidant-free conditions that this strategy offers, the reaction was successfully applied to a wide variety of alkynyl dipolarophiles, demonstrating the tolerance of this approach to diverse functional groups. In particular, we have shown that the method was compatible with biological molecules such as peptides and peptide nucleic acids (PNA). This protocol constitutes another example of metal-free 1,3-dipolar cycloaddition leading to the regioselective formation of isoxazoles.

TEMPO-mediated aliphatic C-H Oxidation with Oximes and hydrazones

A method for aliphatic C-H bond oxidation of oximes and hydrazones mediated by 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO) has been developed, which enables the concise assembly of substituted isoxazole and pyrazole skeletons.