220243-57-2

Basic information

• Product Name: 1-[benzyl(2-hydroxypentyl)amino]-2-pentanol
• CAS NO: 220243-57-2
• Molecular Weight: 279.423
• Mol File: 220243-57-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[benzyl(2-hydroxypentyl)amino]-2-pentanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[benzyl(2-hydroxypentyl)amino]-2-pentanol(220243-57-2)
• EPA Substance Registry System: 1-[benzyl(2-hydroxypentyl)amino]-2-pentanol(220243-57-2)

Safety Data

• Hazardous Substances Data: 220243-57-2(Hazardous Substances Data)

Upstream product

• 1003-14-1 2-pentyloxirane 
• 100-46-9 benzylamine 

Relevant articles and documents

Collagen cross-links: Synthesis of pyridinoline, deoxypyridinoline and their analogues

An efficient chiral synthesis of (S,S)-(-)-3g, a key intermediate for the preparation of collagen cross-links pyridinoline (Pyd, 1) and deoxypyridinoline (Dpd, 2) was achieved from (4S)-5(tert-butoxy)-4-[(tert- butoxycarbonyl)amino]-5-oxopentanoic acid (21b). Quaternization of (S,S)-(- )-3g with iodide (2S, 5R)-(+)-4a followed by hydrolysiS provided a first chiral synthesis of natural (+)-Pyd (1). 1-(2S)-(+)-Pyd (1) was also synthesized from (S,S)-(-)-3g and iodide (2S, 5S)-(+)-4a. Similarly, quaternization of (S,S)-(-)-3g with iodide (2S)-(-)-4b, which was prepared from (2S)-(-)-6-amino-2[(tert-butoxycarbonyl)amino]hexanoic acid (31) in three steps, followed by hydrolysis afforded natural (+)-Dpd (2) in 5.3% overall yield. Also, the synthesis of racemic Dpd [(±)-2] and a variety of its analogues is presented.