220243-81-2 Usage
General Description
"TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)-6-HYDROXYHEXANOATE" is a chemical compound that belongs to the tert-butyl esters class. It is commonly used as a building block in organic synthesis and pharmaceutical research. TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)-6-HYDROXYHEXANOATE is also known for its potential use in drug delivery systems and as a protective group in peptide synthesis. TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)-6-HYDROXYHEXANOATE has a molecular formula of C15H29NO5 and a molecular weight of 303.39 g/mol. Its properties and reactivity make it a valuable tool in the development of new products and medications.
Check Digit Verification of cas no
The CAS Registry Mumber 220243-81-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,2,4 and 3 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 220243-81:
(8*2)+(7*2)+(6*0)+(5*2)+(4*4)+(3*3)+(2*8)+(1*1)=82
82 % 10 = 2
So 220243-81-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H29NO5/c1-14(2,3)20-12(18)11(9-7-8-10-17)16-13(19)21-15(4,5)6/h11,17H,7-10H2,1-6H3,(H,16,19)
220243-81-2Relevant articles and documents
Collagen cross-links: Synthesis of pyridinoline, deoxypyridinoline and their analogues
Adamczyk, Maciej,Johnson, Donald D.,Reddy, Rajarathnam E.
, p. 63 - 88 (2007/10/03)
An efficient chiral synthesis of (S,S)-(-)-3g, a key intermediate for the preparation of collagen cross-links pyridinoline (Pyd, 1) and deoxypyridinoline (Dpd, 2) was achieved from (4S)-5(tert-butoxy)-4-[(tert- butoxycarbonyl)amino]-5-oxopentanoic acid (21b). Quaternization of (S,S)-(- )-3g with iodide (2S, 5R)-(+)-4a followed by hydrolysiS provided a first chiral synthesis of natural (+)-Pyd (1). 1-(2S)-(+)-Pyd (1) was also synthesized from (S,S)-(-)-3g and iodide (2S, 5S)-(+)-4a. Similarly, quaternization of (S,S)-(-)-3g with iodide (2S)-(-)-4b, which was prepared from (2S)-(-)-6-amino-2[(tert-butoxycarbonyl)amino]hexanoic acid (31) in three steps, followed by hydrolysis afforded natural (+)-Dpd (2) in 5.3% overall yield. Also, the synthesis of racemic Dpd [(±)-2] and a variety of its analogues is presented.
