220285-03-0Relevant articles and documents
Synthesis of D- And L-carbocyclic nucleosides via rhodium-catalyzed asymmetric hydroacylation as the key step
Marce, Patricia,Diaz, Yolanda,Matheu, M. Isabel,Castillon, Sergio
supporting information; experimental part, p. 4735 - 4738 (2009/05/31)
(Chemical Equation Presented) D- and L-carbocyclic nucleosides were obtained by a new procedure involving an enantioselective rhodium/duphos- catalyzed hydroacylation reaction as the key step. The 3-hydroxymethyl- cyclopentanol intermediate was obtained by stereoselective reduction of ketone and by dynamic kinetic resolution (DKR).
Bisubstrate inhibitors for the enzyme catechol O-methyltransferase (COMT): Dramatic effects of ribose modifications on binding affinity and binding mode
Lerner, Christian,Siegrist, Romain,Schweizer, Eliane,Diederich, Francois,Gramlich, Volker,Jakob-Roetne, Roland,Zuercher, Gerhard,Borroni, Edilio
, p. 1045 - 1062 (2007/10/03)
Inhibition of the enzyme catechol O-methyltransferase (COMT) is of significant interest in the therapy of Parkinson's disease. Described herein are structural analogs of the potent bisubstrate inhibitor (-)-1 (IC50 = 9 nM; Table 1) for COMT, wi
Dideoxycarbocyclic nucleosides
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, (2008/06/13)
Antiviral and antitumor compounds are disclosed of general formula: STR1 wherein Z is H, OH or NH2, Y is CH or N, the bond indicated by C1 '--C2 ' is absent or, in combination with the C1 '--C2 ' bond is the unit CH=CH, and X is selected from the group consisting of H, N(R2), SR, OR or halogen, wherein R is H, lower (C1 -C4)alkyl, aryl or mixtures thereof, and the pharmaceutically acceptable salts thereof.