220395-81-3

Basic information

• Product Name: [2-(3,5-dichloro-phenyl)-pent-4-enyl]-methyl-amine
• CAS NO: 220395-81-3
• Molecular Weight: 244.164
• Mol File: 220395-81-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [2-(3,5-dichloro-phenyl)-pent-4-enyl]-methyl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(3,5-dichloro-phenyl)-pent-4-enyl]-methyl-amine(220395-81-3)
• EPA Substance Registry System: [2-(3,5-dichloro-phenyl)-pent-4-enyl]-methyl-amine(220395-81-3)

Safety Data

• Hazardous Substances Data: 220395-81-3(Hazardous Substances Data)

Upstream product

• 51719-65-4 2-(3,5-dichlorophenyl)acetic acid 

Downstream Products

• 209349-08-6 C₂₉H₃₂Cl₂N₂O₂S₂ 

Relevant articles and documents

Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: Structure-activity relationships for substituted 2-aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes

(2S)-2-(3,4-Dichlorophenyl)-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-[spiro(2 ,3-dihydrobenzthiophene-3,4′-piperidin-1′yl)]butane S-oxide (3) has been identified as a potent CCR5 antagonist lead structure having an IC50 = 35 nM. Herein, we describe the structure-activity relationship studies directed toward the requirement for and optimization of the C-2 phenyl fragment. The phenyl was found to be important for CCR5 antagonism and substitution was limited to small moieties at the 3-position (13 and 16: X = H, 3-F, 3-Cl, 3-Me).