220510-17-8

Basic information

• Product Name: 5-(PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE
• Synonyms: 5-(PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE;5-(Pyrrolidin-1-ylsulfonyl)indoline-2,3-dione;5-(1-pyrrolidinylsulfonyl)-1H-Indole-2,3-dione
• CAS NO: 220510-17-8
• Molecular Formula: C₁₂H₁₂N₂O₄S
• Molecular Weight: 280.3
• Mol File: 220510-17-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE(220510-17-8)
• EPA Substance Registry System: 5-(PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE(220510-17-8)

Safety Data

• Hazardous Substances Data: 220510-17-8(Hazardous Substances Data)

Usage

General Description

5-(pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione is a chemical compound with a heterocyclic ring structure. It is a sulfonamide derivative of 1H-indole-2,3-dione, containing a pyrrolidine ring attached to the sulfur atom. 5-(PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE has potential applications in medicinal chemistry and pharmaceutical research due to its ability to modulate biological activity through interactions with proteins and enzymes. Its structural features make it a promising candidate for the development of new drugs targeting various diseases and disorders. Additionally, the sulfonamide group provides an opportunity for further structural modification to enhance its biochemical properties and therapeutic potential.

Upstream product

• 123-75-1 pyrrolidine 
• 132898-96-5 5-chlorosulfonylisatin 
• 80789-74-8 5-isatinsulfonic acid sodium salt 
• 91-56-5 indole-2,3-dione 
• 93783-15-4 3,3-dichloro-2-oxoindoline-5-sulfonyl chloride 

Downstream Products

• 1092522-42-3 1-(4-fluorobenzyl)-5-(pyrrolidine-1-sulfonyl)isatin 
• 1144853-67-7 1-benzyl-5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-dione 
• 1144853-71-3 1-(4-methoxybenzyl)-5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-dione 
• 1144853-75-7 1-(3,4-dichlorobenzyl)-5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-dione 

Relevant articles and documents

Efficient synthesis, biological evaluation, and docking study of isatin based derivatives as caspase inhibitors

ABTRACT: In this paper, a new series of isatin-sulphonamide based derivatives were designed, synthesised and evaluated as caspase inhibitors. The compounds containing 1-(pyrrolidinyl)sulphonyl and 2-(phenoxymethyl)pyrrolidin-1-yl)sulphonyl substitution at C5 position of isatin core exhibited better results compared to unsubstituted derivatives. According to the results of caspase inhibitory activity, compound 20d showed moderate inhibitory activity against caspase-3 and ?7 in?vitro compared to Ac-DEVD-CHO (IC50 = 0.016 ± 0.002 μM). Among the studied compounds, some active inhibitors with IC50s in the range of 2.33–116.91 μM were identified. The activity of compound 20d was rationalised by the molecular modelling studies exhibiting the additional van der Waals interaction of N-phenylacetamide substitution along with efficacious T-shaped π-π and pi-cation interactions. The introduction of compound 20d with good caspase inhibitory activity will help researchers to find more potent agents.

Pyrimidoindolones and methods for using same

Novel pyrimidoindolone compounds are disclosed. Methods of using the pyrimidoindolone compounds and compositions containing the compounds in the treatment and/or prevention of disease and other conditions related to inflammation, neurodegeneration, osteoarthritis and apoptosis are also disclosed.