220597-17-1

Basic information

• Product Name: (4R,5R)-5-acetoxy-4-[(3,4-dimethoxyphenyl)bis(phenylthio)methyl]dihydrofuran-2(3H)-one
• Synonyms: (4R,5R)-5-acetoxy-4-[(3,4-dimethoxyphenyl)bis(phenylthio)methyl]dihydrofuran-2(3H)-one
• CAS NO: 220597-17-1
• Molecular Weight: 510.632
• Mol File: 220597-17-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4R,5R)-5-acetoxy-4-[(3,4-dimethoxyphenyl)bis(phenylthio)methyl]dihydrofuran-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5R)-5-acetoxy-4-[(3,4-dimethoxyphenyl)bis(phenylthio)methyl]dihydrofuran-2(3H)-one(220597-17-1)
• EPA Substance Registry System: (4R,5R)-5-acetoxy-4-[(3,4-dimethoxyphenyl)bis(phenylthio)methyl]dihydrofuran-2(3H)-one(220597-17-1)

Safety Data

• Hazardous Substances Data: 220597-17-1(Hazardous Substances Data)

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 108-98-5 thiophenol 
• 60354-22-5 4-[Bis(phenylsulfanyl)methyl]-1,2-dimethoxybenzene 
• 160425-71-8 (4R)-acetic acid 5-oxo-2,5-dihydrofuran-2-yl ester 

Downstream Products

• 157238-68-1 (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxyphenyl)methyl]furan-2(3H)-one 
• 108102-77-8 (R)-4-(3,4-dimethoxybenzyl)dihydrofuran-2(3H)-one 

Relevant articles and documents

Synthesis and pharmacological characterisation of arctigenin analogues as antagonists of AMPA and kainate receptors

(-)-Arctigenin and a series of new analogues have been synthesised and then tested for their potential as AMPA and kainate receptor antagonists of human homomeric GluA1 and GluK2 receptors expressed in HEK293 cells using a Ca2+ influx assay. In general, these compounds showed antagonist activity at both receptors with greater activity evident at AMPARs. Schild analysis indicates that a spirocyclic analogue 6c acts as a non-competitive antagonist. Molecular docking studies in which 6c was docked into the X-ray crystal structure of the GluA2 tetramer suggest that (-)-arctigenin and its analogues bind in the transmembrane domain in a similar manner to the known AMPA receptor non-competitive antagonists GYKI53655 and the antiepileptic drug perampanel. The arctigenin derivatives described herein may serve as novel leads for the development of drugs for the treatment of epilepsy. This journal is