220615-62-3

Basic information

• Product Name: 1-((4'-butoxy(1,1'-biphenyl)-4-yl)thio)-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-propanone
• Synonyms: 1-((4'-butoxy(1,1'-biphenyl)-4-yl)thio)-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-propanone
• CAS NO: 220615-62-3
• Molecular Weight: 440.563
• Mol File: 220615-62-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-((4'-butoxy(1,1'-biphenyl)-4-yl)thio)-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-propanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((4'-butoxy(1,1'-biphenyl)-4-yl)thio)-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-propanone(220615-62-3)
• EPA Substance Registry System: 1-((4'-butoxy(1,1'-biphenyl)-4-yl)thio)-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-propanone(220615-62-3)

Safety Data

• Hazardous Substances Data: 220615-62-3(Hazardous Substances Data)

Upstream product

• 220616-31-9 3-(3-bromo-2-oxopropyl)-5,5-dimethylimidazolidine-2,4-dione 
• 106-53-6 para-bromobenzenethiol 
• 105365-51-3 4-butoxyphenylboronic acid 
• 220615-61-2 3-(3-(4-bromophenylsulfanyl)-2-oxopropyl)-5,5-dimethylimidazolidine-2,4-dione 

Relevant articles and documents

Phenoxyphenyl sulfone N-formylhydroxylamines (Retrohydroxamates) as potent, selective, orally bioavailable matrix metalloproteinase inhibitors

A novel series of sulfone N-formylhydroxylamines (retrohydroxamates) have been investigated as matrix metalloproteinases (MMP) inhibitors. The substitution of the ether linkage of ABT-770 (5) with a sulfone group 13a led to a substantial increase in activity against MMP-9 but was accompanied by a loss of selectivity for inhibition of MMP-2 and -9 over MMP-1 and diminished oral exposure. Replacement of the biphenyl P1′ substituent with a phenoxyphenyl group provided compounds that are highly selective for inhibition of MMP-2 and -9 over MMP-1. Optimization of the substituent adjacent to the retrohydroxamate center in this series led to the clinical candidate ABT-518 (6), a.highly potent, selective, orally bioavailable MMP inhibitor that has been shown to significantly inhibit tumor growth in animal cancer models.