220619-73-8 Usage
Description
3-Methyl-5-[(1S,2S)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl]-2(E),4(E)-pentadienoic acid is a complex organic compound characterized by its unique molecular structure. It is a derivative of pentadienoic acid with a cyclopropyl group and a tetrahydronaphthalenyl group attached to its carbon chain. This molecule exhibits specific stereochemistry and functional groups that may contribute to its potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
3-Methyl-5-[(1S,2S)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl]-2(E),4(E)-pentadienoic acid is used as an active pharmaceutical ingredient for the development of novel drugs targeting various diseases. Its unique structure and functional groups may provide specific biological activities, making it a promising candidate for drug discovery and development.
Used in Chemical Synthesis:
In the chemical industry, 3-Methyl-5-[(1S,2S)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl]-2(E),4(E)-pentadienoic acid can be used as a key intermediate in the synthesis of more complex molecules. Its cyclopropyl and tetrahydronaphthalenyl moieties can be further modified or used as building blocks for the creation of new compounds with specific applications.
Used in Research and Development:
3-Methyl-5-[(1S,2S)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl]-2(E),4(E)-pentadienoic acid can also be utilized in academic and industrial research settings to study its properties, reactivity, and potential interactions with other molecules. Understanding its behavior in various chemical reactions can lead to the discovery of new synthetic routes and applications in different fields.
Used in Immune Modulation and Cancer Treatment:
As mentioned in the provided materials, iso IRX-A, which may be related to the compound in question, is used in the preparation of rexinoids and compositions containing them for immune modulation and treatment of cancer. This suggests that 3-Methyl-5-[(1S,2S)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl]-2(E),4(E)-pentadienoic acid could potentially be used in a similar capacity, contributing to the development of new therapies for immune-related disorders and cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 220619-73-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,6,1 and 9 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 220619-73:
(8*2)+(7*2)+(6*0)+(5*6)+(4*1)+(3*9)+(2*7)+(1*3)=108
108 % 10 = 8
So 220619-73-8 is a valid CAS Registry Number.
220619-73-8Relevant articles and documents
Enantioselective syntheses of potent retinoid X receptor ligands: Differential biological activities of individual antipodes
Vuligonda,Thacher,Chandraratna
, p. 2298 - 2303 (2001)
The synthesis and characterization of chiral RXR selective ligands are described. The enantiomeric acids 2 and 3 were synthesized employing an enantioselective cylopropanation procedure as the key step. Compound 2, with an S,S configuration at C-9 and C-10, is a potent RXR agonist devoid of any RAR activity. The R,R enantiomer 3 is a weak RXR agonist and has demonstrable RAR activity in the receptor transactivation assays. The potent RXR activity of 2 was further confirmed in a hyperglycemic animal model (db/db mice). Compound 2 lowered glucose by 50% by day 7 at 2 mg/kg, whereas 3 had no effect at the same dosage. This further supports the contention that RXR mediated gene transcription is involved in the antidiabetic effects of RXR ligands.
Cobalt-Catalyzed Diastereo- and Enantioselective Hydroalkenylation of Cyclopropenes with Alkenylboronic Acids
Zhang, Haiyan,Huang, Wei,Wang, Tongtong,Meng, Fanke
supporting information, p. 11049 - 11053 (2019/07/17)
Catalytic diastereo- and enantioselective hydroalkenylation of 3,3-disubstituted cyclopropenes with readily accessible alkenylboronic acids, promoted by a chiral phosphine/Co complex, is presented. Such a process constitutes the unprecedented and direct i
