220623-04-1

Basic information

• Product Name: (1R,1aR,1bS,4R,5aS)-5-Oxo-4-phenyl-hexahydro-3-oxa-4a-aza-cyclopropa[a]pentalene-1-carboxylic acid methyl ester
• Synonyms: (1R,1aR,1bS,4R,5aS)-5-Oxo-4-phenyl-hexahydro-3-oxa-4a-aza-cyclopropa[a]pentalene-1-carboxylic acid methyl ester
• CAS NO: 220623-04-1
• Molecular Weight: 273.288
• Mol File: 220623-04-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,1aR,1bS,4R,5aS)-5-Oxo-4-phenyl-hexahydro-3-oxa-4a-aza-cyclopropa[a]pentalene-1-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,1aR,1bS,4R,5aS)-5-Oxo-4-phenyl-hexahydro-3-oxa-4a-aza-cyclopropa[a]pentalene-1-carboxylic acid methyl ester(220623-04-1)
• EPA Substance Registry System: (1R,1aR,1bS,4R,5aS)-5-Oxo-4-phenyl-hexahydro-3-oxa-4a-aza-cyclopropa[a]pentalene-1-carboxylic acid methyl ester(220623-04-1)

Safety Data

• Hazardous Substances Data: 220623-04-1(Hazardous Substances Data)

Upstream product

• 103548-67-0 (Dimethylsulfuranyliden)essigsaeure-methylester 
• 134107-65-6 (3R,7aS)-3-phenyl-3,7a-dihydro-1H-pyrrolo[1,2-c]oxazol-5-one 
• 103201-79-2 (3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one 
• 220623-03-0 (1S,1aR,1bS,4R,5aS)-5-Oxo-4-phenyl-hexahydro-3-oxa-4a-aza-cyclopropa[a]pentalene-1-carboxylic acid methyl ester 

Downstream Products

• 220623-03-0 (1S,1aR,1bS,4R,5aS)-5-Oxo-4-phenyl-hexahydro-3-oxa-4a-aza-cyclopropa[a]pentalene-1-carboxylic acid methyl ester 
• 220623-20-1 (1S,2S,5R,6R)-3-aza-3-<(tert-butyl)oxycarbonyl>-6-(((imino(((2,4,6-trimethylphenyl)sulfonyl)amino)methyl)amino)methyl)bicyclo<3.1.0>hexyl-2-methanol 
• 220623-18-7 (1S,2S,5R,6R)-3-aza-3-benzyl-6-(((imino(((2,4,6-trimethylphenyl)sulfonyl)amino)methyl)amino)methyl)bicyclo<3.1.0>hexyl-2-methanol 
• 220623-21-2 C₂₂H₃₂N₄O₅S 
• 220623-19-8 C₁₇H₂₆N₄O₃S 
• 220623-25-6 (1R,2S,5S,6R)-3-aza-3-<(tert-butyl)oxycarbonyl>-6-methoxycarbonylbicyclo<3.1.0>hexyl-2-carboxylic acid 
• 220623-16-5 (1S,2S,3S,4S,7R)-6-aza-8-oxa-5-oxo-7-phenyltricyclo<4.3.0.0<2,4>>nonane-3-carboxamide 
• 220623-24-5 (1R,2S,5S,6R)-3-aza-3-<(tert-butyl)oxycarbonyl>-6-methoxycarbonylbicyclo<3.1.0>hexyl-2-methanol 
• 220623-23-4 (1R,2S,5S,6R)-3-aza-3-benzyl-6-methoxycarbonylbicyclo<3.1.0>hexyl-2-methanol 
• 220623-17-6 (1S,2S,5S,6R)-6-(aminomethyl)-3-aza-3-benzylbicyclo<3.1.0>hexyl-2-methanol 

Relevant articles and documents

Cyclopropanation reactions of pyroglutamic acid-derived synthons with akylidene transfer reagents

The cyclopropanation of unsaturated lactams 1 and 3 derived from pyroglutamic acid with nucleophilic alkylidene transfer reagents is investigated. Good-to-modest yields of cyclopropanes were obtained with most sulfur ylides explored. Syn/anti selectivity was found to be dependent on the synthon as well as the sulfur ylide. This cyclopropanation methodology is used in the synthesis of arginine and glutamic acid analogues.