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220673-95-0

220673-95-0

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  • L-Isoleucinamide,D-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-lysyl-L-methionyl-L-isoleucyl-L-a-glutamyl-L-isoleucyl-L-a-glutamyl-L-lysyl-L-glutaminyl-L-a-glutamyl-L-lysyl-L-a-glutamyl-L-ly

    Cas No: 220673-95-0

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  • Zibo Hangyu Biotechnology Development Co., Ltd
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  • L-Isoleucinamide,D-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-lysyl-L-methionyl-L-isoleucyl-L-a-glutamyl-L-isoleucyl-L-a-glutamyl-L-lysyl-L-glutaminyl-L-a-glutamyl-L-lysyl-L-a-glutamyl-L-ly

    Cas No: 220673-95-0

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220673-95-0 Usage

Enzyme inhibitor

This highly selective CRF2 antagonist (MW = 3650.29 g/mol; CAS 220673-95-0; Sequence: D-Phe-His-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile- Glu-Lys-Gln-Glu-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2; Solubility: 5 mg/mL H2O; Alternate Name: [D-Phe 11 ,His 12 ]-Sauvagine (11- 40)) targets human Corticotropin-Releasing hormone (CRH) Receptor-2 subtypes CRF2β (Ki = 1.4 nM), with a much higher value of 154 nM for CRF1. (See also Astressin; K41448) Type-2 GPCRs reside in plasma membranes of hormone-sensitive cells and bind CRH, a peptide hormone and neurotransmitter involved in stress responses. Antisauvagine-30 blocks (pA2 = 8.49) sauvagine-stimulated accumulation of cAMP in HEK-mCRF2β cells. It also prevents stress-enhanced fear conditioning and MEK1/2- dependent activation of ERK1/2 in mice and suggesting a role for protein kinase signaling in the hippocampus and its modulation by CRF2 as a possible link between stress and fear memory.

Check Digit Verification of cas no

The CAS Registry Mumber 220673-95-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,6,7 and 3 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 220673-95:
(8*2)+(7*2)+(6*0)+(5*6)+(4*7)+(3*3)+(2*9)+(1*5)=120
120 % 10 = 0
So 220673-95-0 is a valid CAS Registry Number.

220673-95-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Antisauvagine-30

1.2 Other means of identification

Product number -
Other names D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ILE-NH2

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:220673-95-0 SDS

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