220705-66-8

Basic information

• Product Name: N-[3,4-Difluoro-2-(2,2,2-trifluoro-acetyl)-phenyl]-2,2-dimethyl-propionamide
• CAS NO: 220705-66-8
• Molecular Weight: 309.236
• Mol File: 220705-66-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[3,4-Difluoro-2-(2,2,2-trifluoro-acetyl)-phenyl]-2,2-dimethyl-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3,4-Difluoro-2-(2,2,2-trifluoro-acetyl)-phenyl]-2,2-dimethyl-propionamide(220705-66-8)
• EPA Substance Registry System: N-[3,4-Difluoro-2-(2,2,2-trifluoro-acetyl)-phenyl]-2,2-dimethyl-propionamide(220705-66-8)

Safety Data

• Hazardous Substances Data: 220705-66-8(Hazardous Substances Data)

Upstream product

• 3863-11-4 3,4-difluoroaniline 
• 383-63-1 ethyl trifluoroacetate, 
• 205756-46-3 N-pivaloyl-3,4-difluoroaniline 

Downstream Products

• 252580-35-1 4-cyclopropyl-2-[2,3-difluoro-6-(trityl-amino)-phenyl]-1,1,1-trifluoro-but-3-yn-2-ol 
• 205756-70-3 1-[2,3-difluoro-6-(trityl-amino)-phenyl]-2,2,2-trifluoro-ethanone 

Relevant articles and documents

Synthesis and evaluation of analogs of Efavirenz (SUSTIVA(TM)) as HIV-1 reverse transcriptase inhibitors

Efavirenz (SUSTIVA(TM)) is a potent non-nucleoside reverse transcriptase inhibitor. Due to the observation of breakthrough mutations of the reverse transcriptase enzyme during Efavirenz therapy, we sought to develop an optimized second generation series. To that end, SAR of the substituents on the aromatic ring was undertaken and the results are summarized here. The 5,6-difluoro (4f) and the 6-methoxy (4m) substituted benzoxazinones were determined to be equipotent, and as a result such substitution patterns will be incorporated in second generation scaffolds.