220760-44-1

Basic information

• Product Name: (S)-2-((R)-3-tert-Butoxycarbonylamino-butyrylamino)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester
• CAS NO: 220760-44-1
• Molecular Weight: 887.725
• Mol File: 220760-44-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-((R)-3-tert-Butoxycarbonylamino-butyrylamino)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((R)-3-tert-Butoxycarbonylamino-butyrylamino)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester(220760-44-1)
• EPA Substance Registry System: (S)-2-((R)-3-tert-Butoxycarbonylamino-butyrylamino)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester(220760-44-1)

Safety Data

• Hazardous Substances Data: 220760-44-1(Hazardous Substances Data)

Upstream product

• 159991-23-8 (R)-3-((tert-butoxycarbonyl)amino)butanoic acid 
• 45012-62-2 L-leucine allyl ester 
• 162599-95-3 (R)-3-(3-Chloro-4-methoxy-phenyl)-2-((2E,7E)-(5S,6R)-5-hydroxy-6-methyl-8-phenyl-octa-2,7-dienoylamino)-propionic acid 2,2,2-trichloro-ethyl ester 

Downstream Products

• 220761-32-0 (S)-2-((R)-3-Amino-butyrylamino)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 
• 220761-33-1 (E)-(3S,7R,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-7-methyl-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1-oxa-4,8,11-triaza-cyclohexadec-13-ene-2,5,9,12-tetraone 

Relevant articles and documents

Synthesis and Biological Evaluation of Novel Cryptophycin Analogs with Modification in the β-Alanine Region

Structure modification of the β-alanine region (fragment C) of the potent antimitotic agent cryptophycin was investigated. This includes: (1) introduction of substituents at the previously unsubstituted C7 position of the macrolide ring and (2) replacement of the (2R)-3-amino-2-methyl-propanoic acid (β-alanine) with various (l)-amino acids to give the corresponding 15-membered unnatural cryptophycin analogs.