22078-82-6

Basic information

• Product Name: 2-benzoyl-3-hydroxyindole
• Synonyms: 2-benzoyl-3-hydroxyindole
• CAS NO: 22078-82-6
• Molecular Weight: 237.258
• Mol File: 22078-82-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-benzoyl-3-hydroxyindole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzoyl-3-hydroxyindole(22078-82-6)
• EPA Substance Registry System: 2-benzoyl-3-hydroxyindole(22078-82-6)

Safety Data

• Hazardous Substances Data: 22078-82-6(Hazardous Substances Data)

Upstream product

• 110912-11-3 1-acetyl-2-benzoyl-3-indolinone 

Relevant articles and documents

INTRODUCTION OF ACYL SUBSTITUTENTS AT POSITION 2 OF THE INDOLINONE RING

The acylation of 1-acetyl-3-indolinone at position 2 of the heterocycle was realized by the action of acetic and propionic anhydride in the presence of sulfuric acid.It was shown that the reaction takes place with a high yield through an O-acylation and a Fries rearrangement stage.The Fries rearrangement was used to convert the 1-acetyl-3-hydroxybenzoylindole into 1-acetyl-2-benzoyl-3-indolinone.The same β-diketone and also 1-acetyl-2-(p-chlorobenzoyl)-3-indolinone were obtained by the action of a mixture of acetic anhydride and sulfuric acid on the respective 1-acetyl-2-arylidene- 3-indolinones. 1-Acetyl-3-formyl-3-chloroindole was obtained by the reaction of 1-acetyl-3-indolinone with the Vilsmeier complex obtained from DMFA and phosphorus oxychloride.It was deacylated to 2-formyl-3-chloroindole.