22083-60-9Relevant articles and documents
Total synthesis of (+)-antimycin A3b on solid supports
Iijima, Yusuke,Kimata, Osamu,Decharin, Santida,Masui, Hisashi,Hirose, Yoichiro,Takahashi, Takashi
, p. 4725 - 4732 (2014/08/05)
A straightforward and convergent total synthesis of (+)-antimycin A 3b is reported. Four fragments were assembled on a solid support and the fully functionalized seco acid was cyclized in the solution phase. This synthetic route minimized the n
Total Synthesis of the (+)-Antimycin A Family
Inai, Makoto,Nishii, Takeshi,Tanaka, Ayako,Kaku, Hiroto,Horikawa, Mitsuyo,Tsunoda, Tetsuto
, p. 2719 - 2729 (2011/06/23)
An asymmetric aldol reaction using Oppolzer's sultam has provided a practical and efficient synthetic route (15 steps, overall yield ca. 24%) to 12 compounds of the Antimycin A family and deisovalerylblastmycin, which were obtained in pure form on a 60-300 mg scale. In the syntheses, the nine-membered dilactone ring was constructed successfully by lactonization of a 2-pyridinethiol ester bearing a TIPS group on the 8-OH by using the (CuOTf) 2A·PhH complex. An asymmetric aldol reaction usingOppolzer's sultam has provided a practical and efficient synthetic route (15 steps, overall yield ca. 24%) to 12 compounds of the antimycin A family and deisovalerylblastmycin, which were obtained in pure form on a 60-300 mg scale.
2 Methoxy antimycin a derivatives and methods of use
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, (2008/06/13)
Disclosed are 2-methoxy antimycin derivatives or analogs that modulate apoptosis by binding to the hydrophobic groove of a Bcl-2 family member protein (e.g., Bcl-2 or BCl-xL). The 2-methoxy antimycin derivatives or analogs are used in disclosed
