22084-94-2

Basic information

• Product Name: 7-Methoxy-8-hydroxy-4-MethylcouMarin
• Synonyms: 7-Methoxy-8-hydroxy-4-MethylcouMarin;8-Hydroxy-7-methoxy-4-methyl-2H-1-benzopyran-2-one;4-Methyl-7-methoxy-8-hydroxycoumarin
• CAS NO: 22084-94-2
• Molecular Formula: C11H10O4
• Molecular Weight: 206.1947
• EINECS: -0
• Mol File: 22084-94-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-Methoxy-8-hydroxy-4-MethylcouMarin(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Methoxy-8-hydroxy-4-MethylcouMarin(22084-94-2)
• EPA Substance Registry System: 7-Methoxy-8-hydroxy-4-MethylcouMarin(22084-94-2)

Safety Data

• Hazardous Substances Data: 22084-94-2(Hazardous Substances Data)

Usage

General Description

7-Methoxy-8-hydroxy-4-MethylcouMarin is a chemical compound that belongs to the coumarin family, which is known for its various biological activities. This particular compound has been studied for its potential antioxidant, anti-inflammatory, and anticancer properties. It is also found to have potential in the treatment of neurodegenerative diseases. Additionally, 7-Methoxy-8-hydroxy-4-MethylcouMarin has been shown to exhibit antimicrobial and antiviral activities, making it a promising candidate for the development of new pharmaceuticals. Further research is needed to fully understand the potential applications of this compound in various fields of medicine and biotechnology.

Upstream product

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Relevant articles and documents

Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment

Myeloid cell leukemia-1 (Mcl-1) is a validated and attractive target for cancer therapy. Over-expression of Mcl-1 in many cancers allows cancer cells to evade apoptosis and contributes to their resistance to current chemotherapeutics. In this study, more than thirty coumarin derivatives with different substituents were designed and synthesized, and their Mcl-1 inhibitory activities evaluated using a fluorescence polarization-based binding assay. The results showed that the catechol group was a key constituent for Mcl-1 inhibitory activity of the coumarins, and methylation of the catechol group led to decreased inhibitory activity. The introduction of a hydrophobic electron-withdrawing group at the C-4 position of 6,7-dihydroxycoumarin, enhanced Mcl-1 inhibitory capacity, and a hydrophilic group in this position was unbeneficial to the inhibitory potency. In addition, the introduction of a nitrogen-containing group to the C-5 or C-8 position, which allowed an intramolecular hydrogen bond, was also unfavorable for Mcl-1 inhibition. Among all coumarins tested, 4-trifluoromethyl-6,7-dihydroxycoumarin (Cpd 4) displayed the most potent inhibitory activity towards Mcl-1 (Ki = 0.21 ± 0.02 μM, IC50 = 1.21 ± 0.56 μM, respectively), for which the beneficial effect on taxol resistance was also validated in A549 cells. A strong interaction between Cpd 4 and Mcl-1 in docking simulations further supported the observed potent Mcl-1 inhibition ability of Cpd 4. 3D-QSAR analysis of all tested coumarin derivatives further provides new insights into the relationships linking the inhibitory effects on Mcl-1 and the steric-electrostatic properties of coumarins. These findings could be of great value for medicinal chemists for the design and development of more potent Mcl-1 inhibitors for biomedical applications.