220844-73-5

Basic information

• Product Name: 6-FLUOROQUINOLINE-4-CARBOXYLIC ACID
• Synonyms: 6-FLUOROQUINOLINE-4-CARBOXYLIC ACID;4-Quinolinecarboxylic acid, 6-fluoro-
• CAS NO: 220844-73-5
• Molecular Formula: C10H6FNO2
• Molecular Weight: 191.1585432
• Mol File: 220844-73-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-FLUOROQUINOLINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUOROQUINOLINE-4-CARBOXYLIC ACID(220844-73-5)
• EPA Substance Registry System: 6-FLUOROQUINOLINE-4-CARBOXYLIC ACID(220844-73-5)

Safety Data

• Hazardous Substances Data: 220844-73-5(Hazardous Substances Data)

Usage

General Description

6-Fluoroquinoline-4-carboxylic acid is a chemical compound with the molecular formula C10H6FN1O2. It is a derivative of quinoline and contains a fluorine atom at the 6 position and a carboxylic acid functional group at the 4 position. 6-Fluoroquinoline-4-carboxylic acid has been studied for its potential pharmaceutical and biological applications, including its use as a building block in the synthesis of various pharmaceutical agents and as a potential antitumor and antiviral agent. It has also been investigated for its role as an inhibitor of certain enzymes and as a potential treatment for neurological disorders. Additionally, 6-Fluoroquinoline-4-carboxylic acid has been studied for its potential use in the development of new materials and coatings.

Upstream product

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Relevant articles and documents

Synthesis and biological evaluation of novel 4-(6-substituted quinolin-4-yl)-N-aryl thiazol-2-amine derivatives as potential antimicrobial agents

Cyclocondensation reaction of 4-(2-bromoacetyl)quinolin-1-ium bromide (4a–d) with substituted arylthiourea, (5a–g) afforded 4-(6-substituted quinolin-4-yl)-N-aryl/pyridyl thiazol-2-amine (6a-ab). These newly synthesized derivatives were evaluated for in vitro antibacterial activity against Escherichia coli (NCIM 2574), Proteus mirabilis (NCIM 2388) (Gram-negative strains), Bacillus subtilis (NCIM 2063), Staphylococcus albus (NCIM 2178) (Gram-positive strains) and in vitro antifungal activity against Aspergillus niger (ATCC 504) and Candida albicans (NCIM 3100). Compounds 6a, 6b, 6d, 6f, 6k, and 6l showed moderate to good antibacterial activity against S. albus. Ten derivatives 6c, 6q, 6r, 6s, 6t, 6v, 6w, 6x, 6y, and 6aa, showed moderate to good activity against A. niger. N-[4-(Quinolin-4-yl)-1,3-thiazol-2-yl]pyridin-2-amine presented comparable activity against A. niger with respect to standard drug Rouconazole.

Quinoline formamide compound as well as preparation method and application thereof

The invention discloses quinoline formamide compounds as well as a preparation method and application thereof. Specifically, the invention relates to a compound represented by a formula (I) as shown in the specification or a tautomer, a meso-racemate, a r

NOVEL FAP INHIBITORS

The present invention relates to novel inhibitors having high selectivity and specificity for FAP (fibroblast activation protein). Said inhibitors are useful as a human and/or veterinary medicine, in particular for the treatment and/or prevention of FAP-related disorders such as but not limited to proliferative disorders.