220913-32-6

Basic information

• Product Name: AR-67
• Synonyms: AR-67;Silatecan;XUSKJHCMMWAAHV-SANMLTNESA-N
• CAS NO: 220913-32-6
• Molecular Formula: C26H30N2O5Si
• Molecular Weight: 478.6123
• Mol File: 220913-32-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 740°Cat760mmHg
• Flash Point: 401.3°C
• Appearance: /
• Density: 1.32g/cm³
• CAS DataBase Reference: AR-67(CAS DataBase Reference)
• NIST Chemistry Reference: AR-67(220913-32-6)
• EPA Substance Registry System: AR-67(220913-32-6)

Safety Data

• Hazardous Substances Data: 220913-32-6(Hazardous Substances Data)

Usage

General Description

AR-67 is a selective inhibitor of the cyclin-dependent kinase (CDK) that has shown potential for use in cancer treatment. It has been found to target CDK9 and CDK1, leading to cell cycle arrest and apoptosis in cancer cells. AR-67 has also demonstrated anti-tumor activity in preclinical studies, and early clinical trials have shown promising results in treating advanced solid tumors and hematologic malignancies. Additionally, AR-67 has been found to potentiate the effect of other anti-cancer agents, making it a promising candidate for combination therapy. Overall, AR-67 shows potential as a targeted therapy for various types of cancer.

Upstream product

• 220913-29-1 (20S)-10-acetoxy-7-tert-butyldimethylsilylcamptothecin 
• 472961-11-8 7-tert-butyldimethylsilyl-10-phentylmethoxy-camptothecin 
• 410536-43-5 (20S)-7-tert-butyldimethylsilylcamptothecin N-oxide 
• 29681-57-0 tert-butyldimethylsilane 
• 19685-09-7 (S)-10-hydroxycamptothecin 
• 19685-12-2 (S)-4,9-diacetoxy-4-ethyl-1,12-dihydro-4H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione 
• 7689-03-4 camptothecin 
• 203173-70-0 (20S)-7-tert-butyldimethylsilylcamptothecin 
• 220913-33-7 1-(3-tert-butyldimethylsilyl-2-propynyl)-6-iodo-1H-pyridin-2-one 
• 356533-74-9 4-(benzyloxy)phenyl isocyanide 
• 131365-11-2 (3-bromo-1-propynyl)tert-butyldimethylsilane 
• 135294-85-8 tert-butyldimethyl(3-((tetrahydro-2H-pyran-2-yl)oxy)prop-1-yn-1-yl)silane 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 110351-94-5 (4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione 

Relevant articles and documents

Semisynthesis of DB-67 and other silatecans from camptothecin by thiol-promoted addition of silyl radicals

Thiol- or acid-promoted additions of silyl radicals to camptothecin are reported. At 105°C, mixtures of 7-silyl (favored) and 12-silyl camptothecins are formed alongside substantial amounts of recovered camptothecin. At 160°C, 12-silyl isomers are formed

METHODS AND SYSTEMS FOR CAMPTOTHECIN ANALOG SYNTHESIS

Methods and systems for making camptothecin analogs and intermediates are provided. Aspects include safer and lower cost methodologies for making camptothecin analogs and intermediates from synthetic materials. In another aspect, the methods and systems c

Palladium-promoted cascade reactions of isonitriles and 6-iodo-N-propargylpyridones: synthesis of mappicines, camptothecins, and homocamptothecins.

Ambient-temperature reactions of electron-rich aryl isonitriles with substituted 6-iodo-N-propargylpyridones in the presence of silver carbonate and palladium acetate produce 11H-indolizino[1,2-b]quinolin-9-ones in good to excellent yield. Experimental ev